Dekker Job, Misteli Tom
University of Massachusetts Medical School, Worcester, Massachusetts 01605.
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10):a019356. doi: 10.1101/cshperspect.a019356.
To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
为了在细胞核的有限空间内容纳基因组并确保基因表达程序的正确执行，基因组以复杂的方式包装在三维细胞核中。由于染色体广泛的高阶组织，同一或不同染色体上远距离的基因组区域会发生长程相互作用。本文讨论了长程相互作用的性质、其形成机制以及它们在基因调控和基因组维持中新兴的功能作用。
