de Carvalho M F F, Dourado M R, Fernandes I B, Araújo C T P, Mesquita A T, Ramos-Jorge M L
Graduate Program in Dentistry Faculty of Sciences of Health, Federal University of Minas Gerais - UFMG, Av. Pres. Antônio Carlos, 6627 - Campus Pampulha CEP: 31.270-901, Belo Horizonte, MG, Brazil.
Graduate Program in Oral Pathology, Piracicaba Dental School, University of Campinas - Unicamp, Av. Limeira, 901 - Vila Rezende, Piracicaba, SP 13414-903, Brazil.
Arch Oral Biol. 2015 Dec;60(12):1750-5. doi: 10.1016/j.archoralbio.2015.09.009. Epub 2015 Sep 15.
The scientific literature presents conflicting data on a possible causal relationship between marijuana users and the development of head and neck cancer.
This study performed a systematic review with meta-analysis. Articles were selected from various electronic databases using keywords obtained from the Medical Subject Headings (MeSH). After reading by three reviewers and scoring of methodological quality, six articles (totaling nine case-control studies) were assessed with Comprehensive Meta-Analysis(®) software. The value of effect (odds ratio) was calculated, which represented the chance of developing head and neck cancer between individuals who had smoked marijuana in their lifetime in models controlled for age, gender, race, and tobacco consumption.
Approximately 12.6% of cases and 14.3% of controls were marijuana users. The meta-analysis found no association between exposure and disease (OR=1.021; IC 95%=0.912-1.14; p=0.718).
No association between lifetime marijuana use and the development of head and neck cancer was found. The different methods of collection/presentation of results in the selected articles prevented other analyzes from being conducted. Additional studies are needed to assess for long-term effects.
科学文献对于大麻使用者与头颈癌发病之间可能的因果关系给出了相互矛盾的数据。
本研究进行了一项带有荟萃分析的系统评价。使用从医学主题词表（MeSH）中获取的关键词，从各种电子数据库中选取文章。经三位评审员阅读并对方法学质量评分后，使用综合荟萃分析（®）软件对6篇文章（共9项病例对照研究）进行评估。计算效应值（比值比），该值代表在控制了年龄、性别、种族和烟草消费的模型中，终生吸食过大麻的个体患头颈癌的几率。
约12.6%的病例和14.3%的对照为大麻使用者。荟萃分析发现暴露与疾病之间无关联（比值比=1.021；95%置信区间=0.912 - 1.14；p = 0.718）。
未发现终生使用大麻与头颈癌发病之间存在关联。所选文章中结果的不同收集/呈现方法妨碍了进行其他分析。需要开展更多研究来评估长期影响。
