Olsen Elise A
Department of Dermatology, Trent & Erwin Roads, Duke University Medical Center, Durham, NC 27710, USA.
Dermatol Clin. 2015 Oct;33(4):643-54. doi: 10.1016/j.det.2015.06.001.
Primary cutaneous lymphomas (PCLs) are an extremely heterogeneous group of non-Hodgkin lymphomas that manifest in the skin. Their diagnosis is complex and based on clinical lesion type and evaluation of findings on light microscopic examination, immunohistochemistry and molecular analysis of representative skin biopsies. The evaluation, classification, and staging system is unique for mycosis fungoides (MF) and Sézary syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma (CTCL) versus the other subtypes of Non-MF/Non-SS CTCL and the subtypes of cutaneous B-cell lymphoma (CBCL). Since current treatment is stage-based, it is particularly important that the correct diagnosis and stage be ascertained initially. The purpose of this article is to review the current evaluation, diagnosis, classification, staging, assessment techniques, and response criteria for the various types of both T-cell and B-cell PCLs.
原发性皮肤淋巴瘤（PCLs）是一组极其异质性的非霍奇金淋巴瘤，表现于皮肤。其诊断复杂，基于临床病变类型以及对代表性皮肤活检组织进行光镜检查、免疫组化和分子分析的结果评估。蕈样肉芽肿（MF）和 Sézary 综合征（SS）作为皮肤 T 细胞淋巴瘤（CTCL）最常见的亚型，其评估、分类和分期系统与其他非 MF/非 SS CTCL 亚型以及皮肤 B 细胞淋巴瘤（CBCL）亚型不同。由于目前的治疗是基于分期的，因此最初确定正确的诊断和分期尤为重要。本文旨在综述各种 T 细胞和 B 细胞 PCLs 的当前评估、诊断、分类、分期、评估技术及反应标准。
