Chalaka Christopher W, Mahurin Heather M, Tarabadkar Erica, Hippe Daniel S, Loggers Elizabeth T, Shinohara Michi M
University of Washington School of Medicine, Seattle, WA.
Department of Dermatology, Emory University, Atlanta, GA.
Int J Womens Dermatol. 2023 Jun 5;9(2):e085. doi: 10.1097/JW9.0000000000000085. eCollection 2023 Jun.
Patients with cutaneous T-cell lymphoma (CTCL) often experience debilitating symptoms that impair health-related quality of life (HRQoL). Existing evidence for HRQoL differences with respect to gender is conflicting.
To investigate potential gender differences in HRQoL for patients with CTCL.
We performed a cross-sectional study to assess HRQoL in patients with CTCL by partnering with the Cutaneous Lymphoma Foundation to distribute an electronic survey from February to April 2019.
A total of 292 patient responses (66% women, mean age 57 years) were included in the analysis. Most of the cohort had early-stage (IA-IIA) (74%; 162/203) mycosis fungoides (MFs) (87%; 241/279), followed by Sézary syndrome (SS) (12%; 33/279). Women with CTCL experienced significantly worse HRQoL compared with men (Skindex-16: 51±26 vs. 36±26, ≤ 0.001; FACT-G: 69±21 vs. 77±16, = 0.005). This gender difference was present even when controlling for stage of disease. Women experienced worse HRQoL in all three of the Skindex-16 subscales (symptoms: β = 14.0, ≤ 0.001; emotions: β = 15.1, ≤ 0.001; functioning: β = 11.3, = 0.006), but only two of the four FACT-G subscales (physical: β =-2.8, ≤ 0.001; emotional: β = -2.0, = 0.004).
Due to the method of distribution of the survey, we were unable to estimate a participant response rate. Participants' diagnosis and stage were self-reported.
In this cohort women with CTCL experienced significantly worse HRQoL when compared to men. Additional studies are necessary to determine what factors contribute to this gender disparity.
皮肤T细胞淋巴瘤（CTCL）患者常经历使人衰弱的症状，这些症状会损害健康相关生活质量（HRQoL）。关于HRQoL在性别方面差异的现有证据相互矛盾。
调查CTCL患者HRQoL方面潜在的性别差异。
我们开展了一项横断面研究，通过与皮肤淋巴瘤基金会合作，于2019年2月至4月分发电子调查问卷，以评估CTCL患者的HRQoL。
分析纳入了总共292份患者回复（66%为女性，平均年龄57岁）。大多数队列患者患有早期（IA-IIA）蕈样肉芽肿（MF）（74%；162/203）（87%；241/279），其次是塞扎里综合征（SS）（12%；33/279）。与男性相比，CTCL女性患者的HRQoL明显更差（Skindex-16：51±26对36±26，P≤0.001；FACT-G：69±21对77±16，P = 0.005）。即使在控制疾病分期后，这种性别差异仍然存在。女性在Skindex-16的所有三个子量表中HRQoL更差（症状：β = 14.0，P≤0.001；情绪：β = 15.1，P≤0.001；功能：β = 11.3，P = 0.006），但在FACT-G的四个子量表中只有两个子量表如此（身体：β = -2.8，P≤0.001；情感：β = -2.0，P = 0.004）。
由于调查问卷的分发方式，我们无法估计参与者的回复率。参与者的诊断和分期为自我报告。
在该队列中，与男性相比，CTCL女性患者的HRQoL明显更差。需要进一步研究以确定导致这种性别差异的因素。
