树莓叶（刺梨）提取物及其成分的抗血栓活性。
Antithrombotic activity of fractions and components obtained from raspberry leaves (Rubus chingii).
机构信息
Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
Department of Pharmacognosy, Shenyang Pharmaceutical University, 48#, Wenhua Road 103, Shenhe District, PR China.
出版信息
Food Chem. 2012 May 1;132(1):181-5. doi: 10.1016/j.foodchem.2011.10.051. Epub 2011 Oct 19.
The 70% ethanol fraction from an aqueous extract of raspberry leaves was shown to be the most antithrombotic fraction in in vitro and in vivo tests. The total flavonoids and phenolics in this fraction were 0.286g/g and 0.518g/g by colorimetry. Six compounds, including salicylic acid, kaempferol, quercetin, tiliroside, quercetin 3-O-β-d-glucopyranoside and kaempferol 3-O-β-d-glucopyranoside, were isolated from the active fraction. Among them, kaempferol, quercetin and tiliroside obviously delayed plasma recalcification time (PRT) in blood.
树莓叶水提物的 70%乙醇级分在体外和体内试验中显示出最强的抗血栓形成作用。该级分中的总黄酮和酚类含量分别为 0.286g/g 和 0.518g/g，比色法测定。从活性部位分离得到 6 种化合物，包括水杨酸、山柰酚、槲皮素、三叶豆苷、槲皮苷 3-O-β-d-吡喃葡萄糖苷和山柰酚 3-O-β-d-吡喃葡萄糖苷。其中，山柰酚、槲皮素和三叶豆苷明显延长了血液的血浆再钙化时间（PRT）。
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