School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China.
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Chin J Nat Med. 2020 Jun;18(6):401-416. doi: 10.1016/S1875-5364(20)30048-0.
Rubus chingii Hu, a member of the rosaceae family, is extensively distributed in China and Japan. Its unripe fruits (Fupenzi in Chinese) have a long history of use as an herbal tonic in traditional Chinese medicine for treating various diseases commonly associated with kidney deficiency, and they are still in use today. Phytochemical investigations on the fruits and leaves of R. chingii indicate the presence of terpenoids, flavonoids, steroids, alkaloids, phenylpropanoids, phenolics, and organic acids. Extracts or active substances from this plant are reported to have various pharmacological properties, including antioxidant, anti-inflammatory, antitumor, antifungal, antithrombotic, antiosteoporotic, hypoglycemic, and central nervous system-regulating effects. This review provides up-to-date information on the botanical characterizations, traditional usages, chemical constituents, pharmacological activities, toxicity, and quality control of R. chingii. Possible directions for future research are also briefly proposed. This review aims to supply fundamental data for the further study of R. chingii and contribute to the development of its clinical use.
刺梨（Rubus chingii Hu）是蔷薇科悬钩子属植物，广泛分布于中国和日本。其未成熟的果实（刺梨果）作为中草药在传统中药中用于治疗各种与肾虚相关的疾病已有悠久的历史，至今仍在使用。对刺梨的果实和叶子的植物化学研究表明，其含有萜类、类黄酮、甾体、生物碱、苯丙素、酚类和有机酸。该植物的提取物或活性物质据称具有多种药理作用，包括抗氧化、抗炎、抗肿瘤、抗真菌、抗血栓形成、抗骨质疏松、降血糖和中枢神经系统调节作用。本综述提供了关于刺梨的植物学特征、传统用途、化学成分、药理活性、毒性和质量控制的最新信息。还简要提出了未来研究的可能方向。本综述旨在为进一步研究刺梨提供基础数据，并为其临床应用的发展做出贡献。
