Department of Pharmacology, Medical Faculty of University of Pavol Jozef Šafárik in Košice, Košice, Slovak Republic.
Institute of Parasitology, Slovak Academy of Science, Košice, Slovak Republic.
Phytother Res. 2022 May;36(5):2042-2060. doi: 10.1002/ptr.7436. Epub 2022 Mar 18.
The high incidence of post-covid symptoms in humans confirms the need for effective treatment. Due to long-term complications across several disciplines, special treatment programs emerge for affected patients, emphasizing multidisciplinary care. For these reasons, we decided to look at current knowledge about possible long-term complications of COVID-19 disease and then present the effect of flavonoids, which could help alleviate or eliminate complications in humans after overcoming the COVID-19 infection. Based on articles published from 2003 to 2021, we summarize the flavonoids-based molecular mechanisms associated with the post-COVID-19 syndrome and simultaneously provide a complex view regarding their prophylactic and therapeutic potential. Review clearly sorts out the outcome of post-COVID-19 syndrome according particular body systems. The conclusion is that flavonoids play an important role in prevention of many diseases. We suggest that flavonoids as critical nutritional supplements, are suitable for the alleviation and shortening of the period associated with the post-COVID-19 syndrome. The most promising flavonoid with noteworthy therapeutic and prophylactic effect appears to be quercetin.
人类中新冠病毒后遗症的高发病率证实了有效治疗的必要性。由于涉及多个学科的长期并发症，出现了针对受影响患者的特殊治疗方案，强调多学科护理。基于这些原因，我们决定研究目前关于 COVID-19 疾病可能的长期并发症的知识，然后介绍类黄酮的作用，类黄酮可能有助于减轻或消除人类在克服 COVID-19 感染后的并发症。根据 2003 年至 2021 年发表的文章，我们总结了与新冠后综合征相关的基于类黄酮的分子机制，并同时提供了关于其预防和治疗潜力的综合观点。综述清楚地按照特定的身体系统对新冠后综合征的结果进行分类。结论是，类黄酮在预防许多疾病方面发挥着重要作用。我们建议将类黄酮作为重要的营养补充剂，适用于缓解和缩短与新冠后综合征相关的时期。最有前途的具有显著治疗和预防作用的类黄酮似乎是槲皮素。
