Kumar Rahul, Trivedi Vinita, Murti Krishna, Dey Akalanka, Singh Jitendra Kumar, Nath A, Das P
National Institute of Pharmaceutical Education and Research, Hajipur, India E-mail :
Asian Pac J Cancer Prev. 2015;16(15):6397-400. doi: 10.7314/apjcp.2015.16.15.6397.
Cervical cancer is the second most common gynecological malignancy worldwide. According to HPV Information Centre, Spain (Aug'2014), in India approximately 1,22,844 women are diagnosed with the disease every year and of them 67,477 die due to the disease. CaCx is said to be mediated by HPV but recent data published reveal the role of Oxidative Stress in different Cancers. Arsenic is also one of the agents for causing Oxidative Stress. Arsenic has been linked with different types of cancer. Arsenic is considered responsible for generation of free radicals and eventually for apoptosis. Early diagnosis of CaCx is presently a matter of concern and clinical presentation in advanced stages become difficult for complete clinical response. For determination of oxidative stress, Malondialdehyde (MDA) was taken as an identifier and arsenic estimation was performed with the help of Atomic Absorption Spectrometer (AAS). RBC count and Haemoglobin levels were performed according to standard protocol. MDA was in direct proportion with arsenic concentration and inversely proportional to RBC and Haemoglobin in CaCx patients. Arsenic is one of the major causative agents for oxidative stress and hence may be a risk factor leading to cancer including CaCx.
宫颈癌是全球第二常见的妇科恶性肿瘤。根据西班牙HPV信息中心（2014年8月）的数据，在印度，每年约有122844名女性被诊断出患有该病，其中67477人死于该病。据说宫颈癌是由人乳头瘤病毒（HPV）介导的，但最近发表的数据揭示了氧化应激在不同癌症中的作用。砷也是导致氧化应激的因素之一。砷与不同类型的癌症有关。砷被认为是自由基产生的原因，最终导致细胞凋亡。目前，宫颈癌的早期诊断是一个令人担忧的问题，晚期的临床表现使得完全的临床反应变得困难。为了测定氧化应激，将丙二醛（MDA）作为一个指标，并借助原子吸收光谱仪（AAS）进行砷含量测定。红细胞计数和血红蛋白水平按照标准方案进行检测。在宫颈癌患者中，MDA与砷浓度成正比，与红细胞和血红蛋白成反比。砷是氧化应激的主要致病因素之一，因此可能是导致包括宫颈癌在内的癌症的一个危险因素。
