宫颈癌患者的氧化应激与抗氧化状态
Oxidative stress and antioxidant status in cervical cancer patients.
作者信息
Naidu M Smita K, Suryakar A N, Swami Sanjay C, Katkam R V, Kumbar K M
机构信息
Department of Biochemistry, Aditya Institute of Medical Sciences, Beed, (Maharashtra).
出版信息
Indian J Clin Biochem. 2007 Sep;22(2):140-4. doi: 10.1007/BF02913333.
Cervical cancer (CaCx) is a global public health problem as it is the second most common cancer leading to the death of women worldwide. Many references revealed that the low levels of antioxidants induce the generation of free radicals leading to DNA damage and further mutations. In the present study attempt have been made to evaluate the levels of serum Lipid peroxide, Nitric Oxide (NO(.)) Erythrocytic-Superoxide Dismutase (RBC-SOD), Vitamin-C, serum Copper (Cu) and serum Zinc (Zn). 120 patients were divided in 4 groups according to the increasing CaCx stages i.e. stage I, II, III & IV respectively. All the patients were around the age group of 25-65 years. 30 healthy women between the same age group were treated as controls. Highly significant increased values of MDA, NO(.) and Cu were observed (p<0.001) whereas the activity of RBC-SOD, levels of Vitamin-C and Zn were significantly decreased in CaCx patients as compared with healthy controls (p<0.001). Cu/Zn ratio was found to be altered in CaCx patients. From our findings it can be concluded that the oxidative stress is induced among CaCx patients, which inturn increases the risk of CaCx.
宫颈癌是一个全球性的公共卫生问题，因为它是导致全球女性死亡的第二大常见癌症。许多参考文献表明，抗氧化剂水平低会诱导自由基的产生，导致DNA损伤和进一步的突变。在本研究中，已尝试评估血清脂质过氧化物、一氧化氮（NO）、红细胞超氧化物歧化酶（RBC-SOD）、维生素C、血清铜（Cu）和血清锌（Zn）的水平。120名患者根据宫颈癌分期增加分为4组，即分别为I期、II期、III期和IV期。所有患者年龄在25至65岁之间。将30名同一年龄组的健康女性作为对照。观察到丙二醛、NO和铜的值显著升高（p<0.001），而与健康对照相比，宫颈癌患者的红细胞超氧化物歧化酶活性、维生素C和锌水平显著降低（p<0.001）。发现宫颈癌患者的铜/锌比值发生了改变。从我们的研究结果可以得出结论，宫颈癌患者中诱导了氧化应激，这反过来又增加了患宫颈癌的风险。
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