Zhu L, Ding X, Zhang D, Yuan Ch, Wang J, Ndegwa E, Zhu G
Acta Virol. 2015 Sep;59(3):221-7. doi: 10.4149/av_2015_03_221.
The generation of antiviral drugs from herbs and other natural resources with traditionally long-confirmed effects is an efficient approach. So far, no herb or components from herbs that could inhibit bovine herpesvirus type 1 (BoHV-1) replication have been described. In this study, the antiviral effect of curcumin, a natural phenolic constituent of the spice turmeric, on BoHV-1 replication was evaluated in cell culture. We demonstrated that curcumin impairs BoHV-1 viral particles and affects the virus post-binding entry process. Furthermore, curcumin upregulated the proportion of the plasma membrane adopting a lipid raft conformation in MDBK cells, which supported the previous reports that curcumin can modulate the lipid bilayer. Though the antiviral mechanism of curcumin on BoHV-1 needs further study, we identified for the first time a component from herb that could inhibit BoHV-1 replication, in vitro.
从具有长期传统验证效果的草药和其他自然资源中开发抗病毒药物是一种有效的方法。到目前为止，尚未有能抑制牛疱疹病毒1型（BoHV-1）复制的草药或其成分的相关描述。在本研究中，在细胞培养中评估了姜黄素（一种姜黄香料中的天然酚类成分）对BoHV-1复制的抗病毒作用。我们证明姜黄素会损害BoHV-1病毒颗粒并影响病毒结合后进入细胞的过程。此外，姜黄素上调了MDBK细胞中采用脂筏构象的质膜比例，这支持了之前关于姜黄素可调节脂质双层的报道。虽然姜黄素对BoHV-1的抗病毒机制需要进一步研究，但我们首次在体外鉴定出一种能抑制BoHV-1复制的草药成分。
