Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.
Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.
Molecules. 2021 Nov 19;26(22):6994. doi: 10.3390/molecules26226994.
The treatment of viral disease has become a medical challenge because of the increasing incidence and prevalence of human viral pathogens, as well as the lack of viable treatment alternatives, including plant-derived strategies. This review attempts to investigate the trends of research on in vitro antiviral effects of curcumin against different classes of human viral pathogens worldwide. Various electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar were searched for published English articles evaluating the anti-viral activity of curcumin. Data were then extracted and analyzed. The forty-three studies (published from 1993 to 2020) that were identified contain data for 24 different viruses. The 50% cytotoxic concentration (CC50), 50% effective/inhibitory concentration (EC50/IC50), and stimulation index (SI) parameters showed that curcumin had antiviral activity against viruses causing diseases in humans. Data presented in this review highlight the potential antiviral applications of curcumin and open new avenues for further experiments on the clinical applications of curcumin and its derivatives.
由于人类病毒病原体的发病率和患病率不断上升，以及缺乏可行的治疗替代品，包括植物衍生策略，病毒疾病的治疗已成为医学挑战。本综述试图调查全球范围内姜黄素对不同类人类病毒病原体的体外抗病毒作用的研究趋势。检索了包括 PubMed、Scopus、Web of Science 和 Google Scholar 在内的各种电子数据库，以查找评估姜黄素抗病毒活性的已发表英文文章。然后提取和分析数据。确定的 43 项研究（发表于 1993 年至 2020 年）包含了 24 种不同病毒的数据。50%细胞毒性浓度 (CC50)、50%有效/抑制浓度 (EC50/IC50) 和刺激指数 (SI) 参数表明，姜黄素对引起人类疾病的病毒具有抗病毒活性。本综述中提供的数据突出了姜黄素的潜在抗病毒应用，并为进一步研究姜黄素及其衍生物的临床应用开辟了新途径。
