Yalcin Muhammed U, Gurses Kadri M, Kocyigit Duygu, Kesikli Sacit A, Tokgozoglu Lale, Guc Dicle, Aytemir Kudret, Ozer Necla
Department of Cardiology, Hakkari State Hospital, Hakkari, Turkey.
Department of Cardiology, Konya Training and Research Hospital, Konya, Turkey.
J Clin Hypertens (Greenwich). 2016 May;18(5):439-43. doi: 10.1111/jch.12703. Epub 2015 Oct 5.
Beta-trace protein (BTP) has emerged as a novel biomarker of cardiovascular risk. In this study, the authors aimed to assess the relationship between BTP levels and presence of atrial fibrillation in patients who had controlled hypertension (HTN) and normal renal function. A total of 80 controlled HTN patients with paroxysmal atrial fibrillation (PAF) and 80 age- and sex-matched controls with controlled HTN were enrolled. Serum BTP levels were measured by enzyme-linked immunosorbent assay. BTP levels were found to be significantly higher in patients with PAF (P<.001). Other parameters including mean systolic and diastolic blood pressure values, serum creatinine levels, and glomerular filtration rate were similar between the two groups. Along with left atrial diameter (odds ratio, 1.504; P<.001), BTP levels (odds ratio, 1.015; P<.001) were independently associated with the presence of PAF. BTP levels were increased in controlled HTN patients with PAF compared with controls, and this association was observed within normal renal functions as reflected by normal glomerular filtration rate.
β-微球蛋白（BTP）已成为心血管风险的一种新型生物标志物。在本研究中，作者旨在评估血压得到控制且肾功能正常的患者中BTP水平与房颤存在之间的关系。总共纳入了80例血压得到控制的阵发性房颤（PAF）高血压患者以及80例年龄和性别匹配、血压得到控制的对照者。采用酶联免疫吸附测定法测量血清BTP水平。结果发现，PAF患者的BTP水平显著更高（P<0.001）。两组之间的其他参数，包括平均收缩压和舒张压值、血清肌酐水平以及肾小球滤过率相似。与左心房直径（比值比，1.504；P<0.001）一样，BTP水平（比值比，1.015；P<0.001）与PAF的存在独立相关。与对照者相比，血压得到控制的PAF高血压患者的BTP水平升高，并且在肾小球滤过率正常所反映的正常肾功能范围内观察到了这种关联。
