利用鼠单克隆抗体对腐蚀艾肯菌脂多糖进行结构分析。

Structural analysis of lipopolysaccharides from Eikenella corrodens by use of murine monoclonal antibodies.

作者信息

Kato T, Takazoe I, Okuda K

机构信息

Department of Microbiology, Tokyo Dental College, Chiba, Japan.

出版信息

Infect Immun. 1989 Feb;57(2):656-9. doi: 10.1128/iai.57.2.656-659.1989.

DOI:10.1128/iai.57.2.656-659.1989

PMID:2643582

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313151/

Abstract

The structure of lipopolysaccharides (LPSs) of Eikenella corrodens was analyzed with prepared murine monoclonal antibodies. A common core epitope was found in three of seven LPS preparations from E. corrodens strains and Fusobacterium nucleatum ATCC 25586. Four E. corrodens LPSs were found to possess an O-side-chain epitope which cross-reacted with LPSs from Fusobacterium necrophorum ATCC 25286 and Capnocytophaga ochracea M-12. Lipid A of E. corrodens LPS shared an epitope common among LPSs from various gram-negative rods.

摘要

用制备的鼠单克隆抗体分析了腐蚀艾肯菌的脂多糖（LPSs）结构。在来自腐蚀艾肯菌菌株和具核梭杆菌ATCC 25586的7种LPS制剂中的3种中发现了一个共同的核心表位。发现4种腐蚀艾肯菌LPS具有一个O侧链表位，该表位与坏死梭杆菌ATCC 25286和微黄二氧化碳嗜纤维菌M-12的LPS发生交叉反应。腐蚀艾肯菌LPS的脂质A在来自各种革兰氏阴性杆菌的LPS中具有一个共同的表位。