Singh Sudhir, Kumar Dharmendra, Lal Atil Kumar
Professor & Head, Department of Orthopaedics, Era's Lucknow Medical College , Lucknow, India .
Assistant Professor, Department of Orthopaedics, King George's Medical University , Lucknow, India .
J Clin Diagn Res. 2015 Aug;9(8):RC04-7. doi: 10.7860/JCDR/2015/14857.6318. Epub 2015 Aug 1.
Osteoporosis, a major health problem in elderly population, especially in post-menopausal females, is diagnosed basically on clinical suspicion and bone mineral density measurement. Dual energy x-ray absorptiometry (DEXA) scan though a gold standard of diagnosis becomes unfit for screening purpose due to its prohibitive cost, unportability and lack of availability of machine.
To assess the diagnostic potential of serum osteocalcin levels in primary osteoporosis.
In a case-control study, 82 post-menopausal females, between 40-70 years, were subjected to measurements of bone mineral density and serum osteocalcin levels. Based on the results of DEXA scan they were divided into two: a) Control group and B) Case group. Case group was further subdivided as Osteopenia and Osteoporosis depending on their t-scores. Correlation between different BMD grades and the levels of serum osteocalcin were analysed statistically.
A negative correlation was found between serum osteocalcin levels and BMD grading. Significant association of age and years since menopause (YSM) was found with serum osteocalcin levels and BMD. No association of BMI and serum osteocalcin was observed with BMD. Statistically significant difference between values of serum osteocalcin in postmenopausal non-osteoporotic women, post-menopausal women with low bone mass (osteopenia) and post-menopausal women with osteoporosis were seen.
Serum osteocalcin level measurement can be used for screening purpose in post-menopausal patients. Subjects can be further assessed by DEXA scan to, if indicated.
骨质疏松症是老年人群尤其是绝经后女性的一个主要健康问题，其诊断主要基于临床怀疑和骨密度测量。双能X线吸收法（DEXA）扫描虽是诊断的金标准，但因其成本高昂、不便携带且设备难以获取，不适用于筛查。
评估血清骨钙素水平在原发性骨质疏松症中的诊断潜力。
在一项病例对照研究中，对82名年龄在40至70岁之间的绝经后女性进行了骨密度和血清骨钙素水平测量。根据DEXA扫描结果，她们被分为两组：a）对照组和b）病例组。病例组根据其t值进一步细分为骨量减少组和骨质疏松组。对不同骨密度等级与血清骨钙素水平之间的相关性进行了统计学分析。
发现血清骨钙素水平与骨密度分级呈负相关。发现年龄和绝经年限（YSM）与血清骨钙素水平和骨密度有显著关联。未观察到体重指数（BMI）与血清骨钙素和骨密度之间的关联。绝经后非骨质疏松女性、绝经后低骨量（骨量减少）女性和绝经后骨质疏松女性的血清骨钙素值存在统计学显著差异。
血清骨钙素水平测量可用于绝经后患者的筛查。如有必要，可通过DEXA扫描对受试者进行进一步评估。
