Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
Front Public Health. 2022 Sep 6;10:979861. doi: 10.3389/fpubh.2022.979861. eCollection 2022.
Drug-induced gingival overgrowth (DIGO) is a frequent adverse medication reaction that is generally caused by cyclosporine, phenytoin, and nifedipine, which belong to the category of immunosuppressants, anticonvulsants, and calcium channel blockers, respectively. This bibliometric analysis aims to depict the main citation characteristics and analyze the research trends in DIGO investigations.
An exhaustive search was performed in the Scopus database to create the bibliometric list of DIGO in the syntax. Furthermore, the information related to the number of citations, drugs related to DIGO, study topic and design, authorship, publication year, journal, contributing institution, country of origin, and the department was extracted.
In total, 399 papers on DIGO were retrieved in this study. The total number of citations and that after the removal of self-citations were 7,814 and 7,314, respectively. The mean number of citations was 19.6 in a range of 0-608. The main paper types were articles (76.94%) and reviews (19.55%). A remarkable increasing trend in the number of citations has been observed since 1994. Cyclosporine (44.89%) is the most commonly used drug that shares a close relationship with DIGO, followed by phenytoin (18.22%), nifedipine (17.93%), and amlodipine (6.81%). The review (27.82%) type constituted the most widely used design in the DIGO studies. According to the top 20 keywords, the risk factors and pathogenesis of DIGO have been prominent topics of research works for several years.
This bibliometric analysis will facilitate the understanding of researchers and clinicians, especially those at the beginning of their careers in periodontology on DIGO, by identifying landmark research and providing an overview of this field.
药物诱导性牙龈过度生长（DIGO）是一种常见的药物不良反应，通常由环孢素、苯妥英钠和硝苯地平引起，分别属于免疫抑制剂、抗惊厥药和钙通道阻滞剂。本计量分析旨在描述 DIGO 研究的主要引文特征和分析研究趋势。
在 Scopus 数据库中进行了全面搜索，以创建 DIGO 的书目列表。此外，还提取了与引文数量、与 DIGO 相关的药物、研究主题和设计、作者、发表年份、期刊、贡献机构、原产国和部门相关的信息。
本研究共检索到 399 篇关于 DIGO 的论文。总引文数和去除自引后的引文数分别为 7814 次和 7314 次。平均引文数为 19.6，范围为 0-608。主要论文类型为文章（76.94%）和综述（19.55%）。自 1994 年以来，引文数量呈显著增加趋势。环孢素（44.89%）是最常用的药物，与 DIGO 关系密切，其次是苯妥英钠（18.22%）、硝苯地平（17.93%）和氨氯地平（6.81%）。综述（27.82%）类型是 DIGO 研究中最广泛使用的设计。根据前 20 个关键词，DIGO 的危险因素和发病机制多年来一直是研究工作的热门话题。
本计量分析将通过确定具有里程碑意义的研究工作，并提供该领域的概述，帮助牙周病学领域的研究人员和临床医生，特别是那些处于职业生涯早期的研究人员和临床医生了解 DIGO。
