Huang Tao, Larsen Kristian Traberg, Møller Niels Christian, Ried-Larsen Mathias, Frandsen Ulrik, Andersen Lars Bo
Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Center of Research in Childhood Health (RICH), Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Prev Med. 2015 Dec;81:367-72. doi: 10.1016/j.ypmed.2015.09.014. Epub 2015 Oct 3.
To examine the effects of a multi-component camp-based intervention on inflammatory markers and adipokines in children.
One hundred and fifteen children were recruited in Odense, Denmark (2012-2014). The participants were randomly allocated to either the day camp intervention arm (DCIA) or the standard intervention arm (SIA). The intervention for the DCIA consisted of a 6-week camp-based intervention and a 46-week family-based intervention. The SIA was offered one weekly physical activity session for 6 weeks and one educational meeting. C-reactive protein (CRP), monocyte chemoattractant protein-1 (MCP1), leptin, and adiponectin were measured in serum at baseline, 6 weeks and 52 weeks.
In comparison with the SIA, the reductions in CRP (P=0.003) and leptin (p<0.001) were larger in the DCIA at 6 weeks. The intervention effects on leptin were significantly mediated by the changes in body fat mass. No intervention effects on CRP and leptin were seen at 52 weeks. No between-group differences in changes in MCP1 and adiponectin were observed at 6 weeks or 52 weeks.
The 6-week camp intervention resulted in reductions in CRP and leptin. The intervention effects did not persist to 52 weeks. The intervention effect on leptin was explained by changes in body fat mass.
探讨基于营地的多组分干预对儿童炎症标志物和脂肪因子的影响。
在丹麦欧登塞招募了115名儿童（2012 - 2014年）。参与者被随机分配到日间营地干预组（DCIA）或标准干预组（SIA）。DCIA的干预包括为期6周的营地干预和为期46周的家庭干预。SIA提供为期6周的每周一次体育活动课程和一次教育会议。在基线、6周和52周时测量血清中的C反应蛋白（CRP）、单核细胞趋化蛋白-1（MCP1）、瘦素和脂联素。
与SIA相比，DCIA在6周时CRP（P = 0.003）和瘦素（p < 0.001）的降低幅度更大。干预对瘦素的影响通过体脂量的变化显著介导。在52周时未观察到对CRP和瘦素的干预效果。在6周或52周时未观察到MCP1和脂联素变化的组间差异。
为期6周的营地干预导致CRP和瘦素降低。干预效果未持续到52周。对瘦素的干预效果由体脂量的变化解释。
