State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Department of Electrical and Computer Engineering, Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
Small. 2015 Dec 2;11(45):6036-43. doi: 10.1002/smll.201501829. Epub 2015 Oct 5.
Plasmonic nanoparticles are commonly used as optical transducers in sensing applications. The optical signals resulting from the interaction of analytes and plamsonic nanoparticles are influenced by surrounding physical structures where the nanoparticles are located. This paper proposes inverse opal photonic crystal hydrogel as 3D structure to improve Raman signals from plasmonic staining. By hybridization of the plasmonic nanoparticles and photonic crystal, surface-enhanced Raman spectroscopy (SERS) analysis of multiplexed protein is realized. It benefits the Raman analysis by providing high-density "hot spots" in 3D and extra enhancement of local electromagnetic field at the band edge of PhC with periodic refractive index distribution. The strong interaction of light and the hybrid 3D nanostructure offers new insights into plasmonic nanoparticle applications and biosensor design.
等离子体纳米粒子通常被用作传感应用中的光学传感器。由于分析物和等离子体纳米粒子之间的相互作用而产生的光学信号受到纳米粒子所在的周围物理结构的影响。本文提出了具有光子晶体的反蛋白石水凝胶结构，以提高等离子体染色的拉曼信号。通过等离子体纳米粒子和光子晶体的杂交，实现了对多指标蛋白质的表面增强拉曼光谱（SERS）分析。通过在 3D 中提供高密度的“热点”和周期性折射率分布的光子晶体带边缘处局部电磁场的额外增强，为拉曼分析提供了便利。光与混合 3D 纳米结构的强烈相互作用为等离子体纳米粒子的应用和生物传感器设计提供了新的思路。
