Seremet Sila, Turan Enver, Erdemir Asli Turgut
Harran University School of Medicine, Sanliurfa, Turkey.
Dermatol Online J. 2015 Aug 15;21(8):13030/qt8q81z5mh.
Nicolau syndrome, also known as embolia cutis medicamentosa, is a well known but very rare complication occuring after intramuscular drug injections and presenting with local intense pain. Immediately after injection the skin blanches and within minutes to hours an erythematous macule develops, which evolves into a livedoid violaceous patch with dendrites. This condition is initially hemorrhagic, then it ulcerates, and eventually heals with an atrophic scar. Many different drugs have been reported to cause Nicolau syndrome . To date there have been no reports of Nicolau syndrome caused by intramuscular oxytocin injection. We would like to report two cases that occured after intramuscular injection of oxytocin.
尼科劳综合征，又称药物性皮肤栓塞，是一种广为人知但极为罕见的并发症，发生于肌肉注射药物后，表现为局部剧痛。注射后皮肤立即变白，数分钟至数小时内出现红斑，进而发展为带有树枝状的青紫色类紫癜斑。这种情况最初是出血性的，随后发生溃疡，最终愈合形成萎缩性瘢痕。据报道，许多不同药物可导致尼科劳综合征。迄今为止，尚无肌肉注射缩宫素引起尼科劳综合征的报告。我们现报告两例肌肉注射缩宫素后发生的病例。
