Adler Carolyn E, Sánchez Alvarado Alejandro
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA; Current address: Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA; Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA.
Trends Cell Biol. 2015 Nov;25(11):687-696. doi: 10.1016/j.tcb.2015.07.008. Epub 2015 Oct 1.
Many of our organs can maintain and repair themselves during homeostasis and injury, as a result of the action of tissue-specific, multipotent stem cells. However, recent evidence from mammalian systems suggests that injury stimulates dramatic plasticity, or transient changes in cell potential, in both stem cells and more differentiated cells. Planarian flatworms possess abundant stem cells, making them an exceptional model for understanding the cellular behavior underlying homeostasis and regeneration. Recent discoveries of cell lineages and regeneration-specific events provide an initial framework for unraveling the complex cellular contributions to regeneration. In this review, we discuss the concept of cellular plasticity in the context of planarian regeneration, and consider the possibility that pluripotency may be a transient, probabilistic state exhibited by stem cells.
由于组织特异性多能干细胞的作用，我们的许多器官在体内平衡和损伤期间能够维持和自我修复。然而，来自哺乳动物系统的最新证据表明，损伤会刺激干细胞和更多分化细胞发生显著的可塑性变化，即细胞潜能的短暂改变。涡虫拥有丰富的干细胞，这使其成为理解体内平衡和再生背后细胞行为的绝佳模型。最近关于细胞谱系和再生特异性事件的发现为阐明细胞对再生的复杂贡献提供了一个初步框架。在这篇综述中，我们在涡虫再生的背景下讨论细胞可塑性的概念，并考虑多能性可能是干细胞表现出的一种短暂的、概率性状态的可能性。
