年轻男性肱动脉内皮功能在整个上午保持稳定。
Brachial artery endothelial function is stable across the morning in young men.
作者信息
Thosar Saurabh S, Wiggins Chad C, Shea Steven A, Wallace Janet P
机构信息
Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, L 606/RJH 1553 A, 97139, Portland, Oregon, USA.
Department of Kinesiology, School of Public Health, Indiana University Bloomington, Bloomington, Indiana, 47405, USA.
出版信息
Cardiovasc Ultrasound. 2015 Oct 5;13:42. doi: 10.1186/s12947-015-0036-1.
BACKGROUND
The morning hours are associated with increased cardiovascular (CV) risk, and vascular endothelial function (VEF) is a strong predictor of CV disease. A diurnal rhythm in VEF has been established but the morning variation in VEF is not well-documented. Thus, we tested if VEF is impaired across the vulnerable morning period.
METHODS
After overnight fasts, eight healthy men (age 26.3 ± 3 yr) underwent assessments of VEF under standardized testing conditions every 2 h from 0700 to 1300 h on two separate days. VEF was estimated following 5 min brachial artery occlusions by hyperemic flow-mediated dilation (FMD).
RESULTS
There was no significant change in FMD or hyperemic shear stimulus across the 6 h vulnerable period on either day, despite changes in physical activity and meals across these periods.
CONCLUSION
In this healthy group of young men, VEF is stable across the vulnerable morning period when typical behaviors occurred (breakfast and physical activity). Future research should focus on the roles of sleep, physical inactivity during sleep and endogenous circadian rhythm in VEF.
背景
早晨时段与心血管（CV）风险增加相关，而血管内皮功能（VEF）是心血管疾病的有力预测指标。VEF的昼夜节律已得到证实，但VEF在早晨的变化情况尚无充分记录。因此，我们测试了在脆弱的早晨时段VEF是否受损。
方法
八名健康男性（年龄26.3±3岁）在隔夜禁食后，于两天的07:00至13:00每隔2小时在标准化测试条件下接受VEF评估。通过充血介导的血流介导舒张（FMD），在肱动脉闭塞5分钟后估计VEF。
结果
尽管在这些时间段内身体活动和饮食有所变化，但在这两天的6小时脆弱时段内，FMD或充血剪切刺激均无显著变化。
结论
在这群健康的年轻男性中，当出现典型行为（早餐和身体活动）时，VEF在脆弱的早晨时段保持稳定。未来的研究应关注睡眠、睡眠期间的身体不活动以及内源性昼夜节律在VEF中的作用。
Zotero 插件