丝状病毒发病机制与免疫逃逸：来自埃博拉病毒和马尔堡病毒的见解
Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.
作者信息
Messaoudi Ilhem, Amarasinghe Gaya K, Basler Christopher F
机构信息
School of Medicine, University of California Riverside, Riverside, California 92521, USA.
The Division of Biology &Biomedical Sciences, Washington University in St. Louis, St. Louis, Missouri 63110, USA.
出版信息
Nat Rev Microbiol. 2015 Nov;13(11):663-76. doi: 10.1038/nrmicro3524. Epub 2015 Oct 6.
Abstract
Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.
摘要
埃博拉病毒和马尔堡病毒属于丝状病毒科，是可导致人类严重疾病的人畜共患病原体，西非最近爆发的埃博拉病毒疫情就凸显了这一点。丝状病毒病的特征是病毒不受控制地复制以及激活导致发病机制的宿主反应。这些现象的背后是病毒蛋白对宿主先天性抗病毒反应，尤其是I型干扰素反应的有效抑制，这使得病毒能够大量复制。在本综述中，我们描述了丝状病毒用于阻断宿主先天性免疫的机制，并讨论了免疫逃逸与丝状病毒发病机制之间的联系。
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