Preuss H G
Department of Medicine, Georgetown University Medical Center, Washington, D.C. 20007.
Am J Hypertens. 1989 Jan;2(1):65-71. doi: 10.1093/ajh/2.1.65.
The existence of an organ-specific, circulating renal growth factor, renotropin, has been established through various bioassays. However, renotropin may be more than a growth factor. The pathogenesis of essential hypertension is unknown, although a humoral agent related to renal metabolism is believed to be responsible, at least in part. In parallel with the development of a renotropin assay, we have measured vasomotor and natriuretic serum activities. Our data suggest that renotropin possesses vasomotor and natriuretic properties. Through one or both properties, renotropin may play an important role in essential hypertension. This possibility is strengthened by observations that: a) many methods to produce experimental hypertension involve elevations of renotropin--a reduction of renal mass and/or prevention of compensatory growth; b) high renotropin activity has been demonstrated in genetically hypertensive rats (SHR); and c) sera containing high renotropic activity stimulate contraction of isolated rat aortic rings and influence organic anion and cation transport.
通过各种生物测定法已证实存在一种器官特异性的循环肾生长因子——肾营养素。然而，肾营养素可能不仅仅是一种生长因子。原发性高血压的发病机制尚不清楚，尽管人们认为一种与肾脏代谢相关的体液因子至少在一定程度上对此负责。在开发肾营养素测定方法的同时，我们测量了血管舒缩和利钠血清活性。我们的数据表明肾营养素具有血管舒缩和利钠特性。通过这一种或两种特性，肾营养素可能在原发性高血压中起重要作用。以下观察结果进一步支持了这一可能性：a）许多产生实验性高血压的方法都涉及肾营养素升高——肾质量减少和/或代偿性生长的预防；b）在遗传性高血压大鼠（SHR）中已证明肾营养素活性很高；c）含有高肾营养活性的血清刺激离体大鼠主动脉环收缩并影响有机阴离子和阳离子转运。
