Averbukh Z, Weissgarten J, Berman S, Cohn M, Modai D
Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Israel.
Am J Nephrol. 1996;16(5):425-30. doi: 10.1159/000169036.
In offspring of uninephrectomized mouse mothers at ages 3, 5 and 7 weeks (n = 8 in each group) fresh and dry kidney weights, protein content, mean number of glomeruli per microscopic field (GN), mean cumulative fractional glomerular area per microscopic field (GA) and mean number of nuclei per glomerulus (GC) were all significantly increased compared to age-matched control offspring of sham nephrectomized mothers. Sera from mice at ages 3 and 5 weeks, offspring of uninephrectomized mothers, stimulated mesangial cell proliferation in culture. Surprisingly, fresh and dry renal weight, GN, GA and GC were all significantly increased in offspring of sham nephrectomized mothers, daughters of uninephrectomized grandmothers. We speculate that elevated maternal renotropin transferred via the placenta introduces a modification in the embryonal interrelationship between renal mass and endogenous renotropin. This modification results in exaggerated embryonal serum renotropic activity extending to puberty. Whether the humoral agent responsible for enhanced mesangial cell proliferation in vitro is identical to renotropin remains to be elucidated.
在3周、5周和7周龄的单侧肾切除小鼠母亲的后代中（每组n = 8），与假肾切除母亲的年龄匹配对照后代相比，新鲜和干燥肾脏重量、蛋白质含量、每个显微镜视野的肾小球平均数量（GN）、每个显微镜视野的平均累积肾小球面积分数（GA）和每个肾小球的细胞核平均数量（GC）均显著增加。3周和5周龄的单侧肾切除母亲后代的小鼠血清在培养中刺激系膜细胞增殖。令人惊讶的是，假肾切除母亲的后代、单侧肾切除祖母的女儿的新鲜和干燥肾脏重量、GN、GA和GC均显著增加。我们推测，通过胎盘传递的母体肾营养素升高会对肾脏质量与内源性肾营养素之间的胚胎相互关系产生改变。这种改变导致胚胎血清促肾生长活性增强并持续到青春期。体外负责增强系膜细胞增殖的体液因子是否与肾营养素相同仍有待阐明。
