Castro Gabriel Perfeito, Medeiros Daniel de Castro, Guarnieri Leonardo de Oliveira, Mourão Flávio Afonso Gonçalves, Pinto Hyorrana Priscila Pereira, Pereira Grace Schenatto, Moraes Márcio Flávio Dutra
Núcleo de Neurociências (NNC), Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil.
Núcleo de Neurociências (NNC), Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil; Centro de Tecnologia e Pesquisa em Magneto-Ressonância, Escola de Engenharia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil.
Epilepsy Behav. 2017 Jun;71(Pt B):243-249. doi: 10.1016/j.yebeh.2015.08.039. Epub 2015 Oct 4.
Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".
来自不同动物模型的越来越多的证据有助于理解癫痫状况与行为异常之间的双向共病关联。一种为增强对高强度声音刺激的癫痫易感性而培育的近交系动物——Wistar听源性大鼠（WAR），接受了多项行为测试：强迫游泳试验（FST）、旷场试验（OFT）、蔗糖偏好试验（SPT）、高架十字迷宫试验（EPM）、社交偏好试验（SP）、埋珠试验（MBT）、抑制性回避试验（IAT）和双向主动回避试验（TWAA）。这些测试的选择旨在研究被认为参与WAR对声音诱发癫痫的固有易感性的潜在回路与与测试表现相关的神经生物学底物之间的相关性。将WAR与其Wistar同类大鼠（即对听源性癫痫有抵抗力的大鼠）进行比较表明，WAR表现出行为绝望特征（如FST不动时间增加），但没有快感缺失行为的证据（如SPT中蔗糖消耗增加）或社交障碍（如SP中幼鼠探索无差异）。此外，测试表明WAR无法正确评估厌恶程度（如OFT、EPM、MBT、IAT和TWAA中的表现）。WAR模型的特殊性为进一步解开行为障碍和癫痫共病背后的神经生物学开辟了新途径。本文是名为“遗传性和反射性癫痫、听源性癫痫和品系：从实验模型到临床”的特刊的一部分。
