MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter.
作者信息
Vais Horia, Tanis Jessica E, Müller Marioly, Payne Riley, Mallilankaraman Karthik, Foskett J Kevin
机构信息
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA.
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6085, USA.
出版信息
Cell Metab. 2015 Oct 6;22(4):533-5. doi: 10.1016/j.cmet.2015.09.015.
Abstract
摘要
相似文献
1
MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter.MCUR1，即CCDC90A，是线粒体钙单向转运体的调节因子。
Cell Metab. 2015 Oct 6;22(4):533-5. doi: 10.1016/j.cmet.2015.09.015.
2
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.CCDC90A（MCUR1）是细胞色素 c 氧化酶组装因子，而不是线粒体钙单向转运体的调节剂。
Cell Metab. 2015 Jan 6;21(1):109-16. doi: 10.1016/j.cmet.2014.12.004.
3
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.MCUR1 是线粒体钙摄取的必需组成部分，可调节细胞代谢。
Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25.
4
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.MCUR1 介导线粒体钙信号促进肝细胞癌细胞存活通过活性氧依赖的 P53 降解。
Antioxid Redox Signal. 2018 Apr 20;28(12):1120-1136. doi: 10.1089/ars.2017.6990. Epub 2017 Nov 1.
5
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.MCUR1是MCU复合物功能的支架因子，并促进线粒体生物能量学。
Cell Rep. 2016 May 24;15(8):1673-85. doi: 10.1016/j.celrep.2016.04.050. Epub 2016 May 12.
6
Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism.人类 MCUR1 的酵母同源物调节线粒体脯氨酸代谢。
Nat Commun. 2020 Sep 25;11(1):4866. doi: 10.1038/s41467-020-18704-1.
7
Importance of mitochondrial calcium uniporter in high glucose-induced endothelial cell dysfunction.线粒体钙单向转运体在高糖诱导的内皮细胞功能障碍中的重要性。
Diab Vasc Dis Res. 2017 Nov;14(6):494-501. doi: 10.1177/1479164117723270. Epub 2017 Aug 4.
8
Analysis of the structure and function of EMRE in a yeast expression system.酵母表达系统中EMRE的结构与功能分析
Biochim Biophys Acta. 2016 Jun;1857(6):831-9. doi: 10.1016/j.bbabio.2016.03.019. Epub 2016 Mar 18.
9
Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) Relieves Mitochondrial Damage Induced by Lipopolysaccharide by Mediating Mitochondrial Ca Homeostasis in Bovine Mammary Epithelial Cells.线粒体钙单向转运蛋白调节因子 1（MCUR1）通过调节牛乳腺上皮细胞中线粒体钙稳态缓解脂多糖诱导的线粒体损伤。
J Agric Food Chem. 2023 May 17;71(19):7278-7288. doi: 10.1021/acs.jafc.2c07494. Epub 2023 May 5.
10
Characterization of MCU-Binding Proteins MCUR1 and CCDC90B - Representatives of a Protein Family Conserved in Prokaryotes and Eukaryotic Organelles.MCU 结合蛋白 MCUR1 和 CCDC90B 的鉴定 - 原核生物和真核细胞器中保守蛋白家族的代表。
Structure. 2019 Mar 5;27(3):464-475.e6. doi: 10.1016/j.str.2018.11.004. Epub 2019 Jan 3.
引用本文的文献
1
Mitochondrial Ca uniporter b (MCUb) regulates neuronal Ca dynamics and resistance to ischemic stroke.线粒体钙单向转运体b（MCUb）调节神经元钙动力学及对缺血性中风的抗性。
Cell Calcium. 2025 Jun;128:103013. doi: 10.1016/j.ceca.2025.103013. Epub 2025 Feb 27.
2
Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.线粒体钙调节在心脏代谢中的作用：健康与疾病。
Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00014.2024. Epub 2024 May 7.
3
Beyond the TCA cycle: new insights into mitochondrial calcium regulation of oxidative phosphorylation.超越三羧酸循环：线粒体钙对氧化磷酸化调节的新见解。
Biochem Soc Trans. 2023 Aug 31;51(4):1661-1673. doi: 10.1042/BST20230012.
4
Post-translational modifications and protein quality control of mitochondrial channels and transporters.线粒体通道和转运蛋白的翻译后修饰与蛋白质质量控制
Front Cell Dev Biol. 2023 Aug 3;11:1196466. doi: 10.3389/fcell.2023.1196466. eCollection 2023.
5
Patch-clamp technique to study mitochondrial membrane biophysics.膜片钳技术在研究线粒体膜生物物理学中的应用。
J Gen Physiol. 2023 Aug 7;155(8). doi: 10.1085/jgp.202313347. Epub 2023 Jun 22.
6
IGF-1 boosts mitochondrial function by a Ca uptake-dependent mechanism in cultured human and rat cardiomyocytes.在培养的人类和大鼠心肌细胞中，胰岛素样生长因子-1（IGF-1）通过一种依赖钙摄取的机制增强线粒体功能。
Front Physiol. 2023 Feb 8;14:1106662. doi: 10.3389/fphys.2023.1106662. eCollection 2023.
7
Modulation of the mitochondrial Ca uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells.不同切应力模式对血管内皮细胞线粒体钙单向转运体复合物亚基表达的调节。
Physiol Rep. 2023 Feb;11(3):e15588. doi: 10.14814/phy2.15588.
8
Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter.线粒体钙单向转运体的离子选择性和通透性机制。
Sci Adv. 2022 Dec 16;8(50):eade1516. doi: 10.1126/sciadv.ade1516.
9
Enhanced NCLX-dependent mitochondrial Ca efflux attenuates pathological remodeling in heart failure.增强的 NCLX 依赖性线粒体钙外流可减轻心力衰竭中的病理性重构。
J Mol Cell Cardiol. 2022 Jun;167:52-66. doi: 10.1016/j.yjmcc.2022.03.001. Epub 2022 Mar 28.
10
Mitochondrial calcium exchange in physiology and disease.线粒体钙交换在生理和疾病中的作用。
Physiol Rev. 2022 Apr 1;102(2):893-992. doi: 10.1152/physrev.00041.2020. Epub 2021 Oct 26.
本文引用的文献
1
Structure and function of the N-terminal domain of the human mitochondrial calcium uniporter.人类线粒体钙单向转运体N端结构域的结构与功能
EMBO Rep. 2015 Oct;16(10):1318-33. doi: 10.15252/embr.201540436. Epub 2015 Sep 3.
2
CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.CCDC90A（MCUR1）是细胞色素 c 氧化酶组装因子，而不是线粒体钙单向转运体的调节剂。
Cell Metab. 2015 Jan 6;21(1):109-16. doi: 10.1016/j.cmet.2014.12.004.
3
The mitochondrial Ca(2+) uniporter complex.线粒体钙离子单向转运体复合物
J Mol Cell Cardiol. 2015 Jan;78:3-8. doi: 10.1016/j.yjmcc.2014.11.015. Epub 2014 Nov 22.
4
EMRE is an essential component of the mitochondrial calcium uniporter complex.EMRE 是线粒体钙单向转运体复合物的必需组成部分。
Science. 2013 Dec 13;342(6164):1379-82. doi: 10.1126/science.1242993. Epub 2013 Nov 14.
5
Activity of the mitochondrial calcium uniporter varies greatly between tissues.线粒体钙单向转运体的活性在不同组织之间差异很大。
Nat Commun. 2012;3:1317. doi: 10.1038/ncomms2325.
6
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.MCUR1 是线粒体钙摄取的必需组成部分，可调节细胞代谢。
Nat Cell Biol. 2012 Dec;14(12):1336-43. doi: 10.1038/ncb2622. Epub 2012 Nov 25.
7
The mitochondrial calcium uniporter is a highly selective ion channel.线粒体钙单向转运体是一种高度选择性的离子通道。
Nature. 2004 Jan 22;427(6972):360-4. doi: 10.1038/nature02246.
Zotero 插件