Lipari Alessio, Farina Elvira, Gerbino Aldo, Lipari Luana
Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Via del Vespro, 129, 90127 Palermo, Italy.
Cerebellum Ataxias. 2015 Oct 6;2:12. doi: 10.1186/s40673-015-0031-1. eCollection 2015.
Many studies are in the literature on the ANP and oxytocin-presence in the brain, but very few studies with controversial results are reported on the presence of these peptides in the cerebellum. This immunohistochemical study investigates on the ANP and oxytocin-presence in the cerebellum of the adult rat and mouse rodents.
This study, firstly, evidences the ANP- immunopositivity in cerebellar cortex of both rat and mouse rodents. In rat the molecular layer presents some few immunopositive fibers, but no neuron resulted immunopositive; the granular and Purkinje cells are immunopositive. In mouse the cerebellar cortex ANP-immunopositivity is present in all layers. The oxytocin-presence in the rat the afferent fibers are immunopositive are in the granular layer; in mouse the OT-immunopositivity is in the molecular layer only.
This study, firstly, shows that ANP and OT are present in the cerebellar cortex both in rat and mouse rodents. In the mouse cerebellar cortex ANP-presence is more diffuse and OT- localization differences in the two species.
文献中有许多关于心房钠尿肽（ANP）和催产素在大脑中存在情况的研究，但关于这些肽在小脑存在情况的研究报道很少，且结果存在争议。这项免疫组织化学研究调查了成年大鼠和小鼠啮齿动物小脑中ANP和催产素的存在情况。
本研究首先证实了大鼠和小鼠啮齿动物小脑皮质中存在ANP免疫阳性。在大鼠中，分子层有一些免疫阳性纤维，但没有神经元呈免疫阳性；颗粒细胞和浦肯野细胞呈免疫阳性。在小鼠中，小脑皮质各层均存在ANP免疫阳性。在大鼠中，传入纤维在颗粒层呈免疫阳性；在小鼠中，催产素免疫阳性仅存在于分子层。
本研究首先表明，大鼠和小鼠啮齿动物的小脑皮质中均存在ANP和催产素。在小鼠小脑皮质中，ANP的存在更为广泛，且两种物种中催产素的定位存在差异。
