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本文引用的文献

1
Prevalences of illicit drug use in people aged 50 years and over from two surveys.50 岁及以上人群中非法药物使用的流行率:两项调查结果。
Age Ageing. 2012 Jul;41(4):553-6. doi: 10.1093/ageing/afs020. Epub 2012 Apr 5.
2
Trends in substance abuse treatment 1998-2008: increasing older adult first-time admissions for illicit drugs.1998-2008 年药物滥用治疗趋势:越来越多的老年初诊患者滥用非法药物。
Am J Geriatr Psychiatry. 2011 Aug;19(8):704-11. doi: 10.1097/JGP.0b013e31820d942b.
3
Cognitive enhancers in the treatment of substance use disorders: clinical evidence.认知增强剂治疗物质使用障碍:临床证据。
Pharmacol Biochem Behav. 2011 Aug;99(2):285-94. doi: 10.1016/j.pbb.2011.04.017. Epub 2011 Apr 29.
4
Illicit and nonmedical drug use among older adults: a review.老年人的非法和非医疗药物使用:综述。
J Aging Health. 2011 Apr;23(3):481-504. doi: 10.1177/0898264310386224. Epub 2010 Nov 17.
5
Clinical profiles, complications, and disability in cocaine-related ischemic stroke.可卡因相关性缺血性脑卒中的临床特征、并发症和残疾。
J Stroke Cerebrovasc Dis. 2011 Sep-Oct;20(5):443-9. doi: 10.1016/j.jstrokecerebrovasdis.2010.02.017. Epub 2010 Sep 2.
6
Cocaine abuse in older adults: an underscreened cohort.老年人中的可卡因滥用:一个筛查不足的队列。
J Am Geriatr Soc. 2010 Feb;58(2):391-2. doi: 10.1111/j.1532-5415.2009.02697.x.
7
Cognitive enhancement as a pharmacotherapy target for stimulant addiction.将认知增强作为治疗兴奋剂成瘾的药物治疗靶点。
Addiction. 2010 Jan;105(1):38-48. doi: 10.1111/j.1360-0443.2009.02791.x.
8
[Initiation cocaine use in elderly patients: a case report].[老年患者首次使用可卡因:一例报告]
Vertex. 2009 Nov-Dec;20(88):418-20.
9
The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health.中年及老年社区成年人物质使用与障碍的流行病学:全国药物使用和健康调查
Am J Geriatr Psychiatry. 2009 Mar;17(3):237-45. doi: 10.1097/JGP.0b013e318190b8ef.
10
Changing profile of abused substances by older persons entering treatment.进入治疗的老年人滥用物质情况的变化
J Nerv Ment Dis. 2008 Dec;196(12):898-905. doi: 10.1097/NMD.0b013e31818ec7ee.

晚年可卡因滥用:病例系列及文献综述

Cocaine Abuse in Later Life: A Case Series and Review of the Literature.

作者信息

Yarnell Stephanie C

机构信息

Department of Psychiatry, Yale University Psychiatry Residency Program, New Haven, Connecticut.

出版信息

Prim Care Companion CNS Disord. 2015 Apr 9;17(2). doi: 10.4088/PCC.14r01727. eCollection 2015.

DOI:10.4088/PCC.14r01727
PMID:26445694
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4560194/
Abstract

OBJECTIVE

To raise awareness about the growing trend of cocaine abuse in later years as an underdiagnosed, undertreated, and comorbid condition in older individuals. Three cases of cocaine use in patients over the age of 50 years in the Malcolm Randall Veterans Medical Center, Gainesville, Florida, within a 10-day span in 2013 are presented.

DATA SOURCES

PubMed was searched using combinations of keywords, including cocaine, addiction, elderly, and aging, to find articles published between 1986 and 2013.

STUDY SELECTION

In total, 37 articles were selected for inclusion on the basis of their relevance to the objective and importance to the representation of cocaine abuse, including international guidelines for addiction.

DATA EXTRACTION

Each article was reviewed for eligibility. Final decisions were made following full-text review.

RESULTS

Cocaine addiction remains a high-morbidity chronic-relapsing illness with few treatment options. A review of the literature shows that late-life cocaine use is sparsely recognized. Of particular interest are the clinical presentations in which a higher index for detection is warranted. The high rate of medical comorbidity associated with cocaine use, especially cerebrovascular deficits, presents special treatment and social challenges.

CONCLUSIONS

As the number of older individuals admitted for substance use continues to climb, clinicians must adapt to the changing demographics by increasing screening, early detection, and treatment options for older persons.

摘要

目的

提高对近年来可卡因滥用这一日益增长趋势的认识,可卡因滥用在老年人中是一种诊断不足、治疗不足且合并其他疾病的情况。本文介绍了2013年在佛罗里达州盖恩斯维尔的马尔科姆·兰德尔退伍军人医疗中心10天内出现的3例50岁以上患者使用可卡因的病例。

数据来源

使用包括可卡因、成瘾、老年人和衰老等关键词组合在PubMed上进行搜索,以查找1986年至2013年发表的文章。

研究选择

根据文章与目标的相关性以及对可卡因滥用代表性的重要性,共选择了37篇文章纳入研究,包括成瘾方面的国际指南。

数据提取

对每篇文章进行资格审查。在全文审查后做出最终决定。

结果

可卡因成瘾仍然是一种高发病率的慢性复发性疾病,治疗选择很少。文献综述表明,晚年使用可卡因的情况很少得到认识。特别值得关注的是那些需要更高检测指标的临床表现。与使用可卡因相关的高医疗合并症发生率,尤其是脑血管缺陷,带来了特殊的治疗和社会挑战。

结论

随着因物质使用而入院的老年人数量持续攀升,临床医生必须通过增加对老年人的筛查、早期检测和治疗选择来适应不断变化的人口结构。