Ostojic Sergej M
Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, Novi Sad, 21000, Serbia.
University of Belgrade School of Medicine, Belgrade, Serbia.
Amino Acids. 2016 Aug;48(8):1867-75. doi: 10.1007/s00726-015-2106-y. Epub 2015 Oct 7.
Guanidinoacetic acid (GAA; also known as glycocyamine or guanidinoacetate) is the natural precursor of creatine, and under investigation as a novel dietary agent. It was first identified as a natural compound in humans ~80 years ago. In the 1950s, GAA's use as a therapeutic agent was explored, showing that supplemental GAA improved patient-reported outcomes and work capacity in clinical populations. Recently, a few studies have examined the safety and efficacy of GAA and suggest potential ergogenic benefits for physically active men and women. The purpose of this review is to examine possible applications of GAA supplementation for exercise performance enhancement, safety, and legislation issues.
胍基乙酸（GAA；也称为胍基乙胺或胍基乙酸盐）是肌酸的天然前体，目前正作为一种新型膳食补充剂进行研究。大约80年前，它首次在人体中被鉴定为天然化合物。20世纪50年代，人们探索了GAA作为治疗剂的用途，结果表明补充GAA可改善临床人群中患者报告的结果和工作能力。最近，一些研究对GAA的安全性和功效进行了研究，并表明其对从事体育活动的男性和女性可能具有增强体能的益处。本综述的目的是探讨补充GAA在提高运动表现、安全性及立法问题方面的可能应用。
