Xiao Jian, Wang Lifen, Chen Yuguang, Xiao Kai
Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Vet Sci. 2025 Jun 5;12(6):551. doi: 10.3390/vetsci12060551.
This study investigated the effects of dietary guanidinoacetic acid (GAA) supplementation on growth performance, carcass traits, meat quality, intestinal morphology, and cecal microbiota composition in yellow-feathered broilers. A total of 360 one-day-old chicks were randomly assigned to five groups with diets containing 0 (control), 300 mg/kg, 600 mg/kg, 900 mg/kg, and 1200 mg/kg GAA. In the initial growth phase, GAA supplementation increased average daily gain (ADG) by 13.01%, 8.97%, and 12.95% for the 300, 600, and 900 mg/kg groups, respectively, and reduced the feed conversion ratio (FCR), though these changes were not statistically significant ( > 0.05). Higher GAA dosages (900 and 1200 mg/kg) improved post-slaughter pH levels in breast muscle, indicating better meat quality, and significantly enhanced intestinal barrier function by increasing villus height and the villus-to-crypt ratio. However, 1200 mg/kg GAA led to a significant increase in serum ALT levels, raising concerns about potential liver stress. Overall, 900 mg/kg GAA supplementation demonstrated the most beneficial effects across various parameters, suggesting it as an optimal dosage to enhance production performance and meat quality in yellow-feathered broilers. Future studies are encouraged to investigate its long-term safety and underlying mechanisms.
本研究调查了日粮中添加胍基乙酸（GAA）对黄羽肉鸡生长性能、胴体性状、肉质、肠道形态和盲肠微生物群组成的影响。总共360只1日龄雏鸡被随机分为五组，日粮中分别含有0（对照组）、300 mg/kg、600 mg/kg、900 mg/kg和1200 mg/kg的GAA。在生长初期，300、600和900 mg/kg组添加GAA分别使平均日增重（ADG）提高了13.01%、8.97%和12.95%，并降低了料重比（FCR），不过这些变化在统计学上不显著（P>0.05）。较高剂量的GAA（900和1200 mg/kg）提高了胸肌宰后pH值，表明肉质更好，并通过增加绒毛高度和绒毛与隐窝比值显著增强了肠道屏障功能。然而，1200 mg/kg的GAA导致血清谷丙转氨酶（ALT）水平显著升高，引发了对潜在肝脏应激的担忧。总体而言，添加900 mg/kg的GAA在各项参数上表现出最有益的效果，表明它是提高黄羽肉鸡生产性能和肉质的最佳剂量。鼓励未来的研究调查其长期安全性及潜在机制。
