用于骨软骨组织工程的分层支架

Stratified Scaffolds for Osteochondral Tissue Engineering.

作者信息

Nooeaid Patcharakamon, Schulze-Tanzil Gundula, Boccaccini Aldo R

机构信息

Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91052, Erlangen, Germany.

Institute of Anatomy, Paracelsus Medical University, Salzburg and Nuremberg, Nuremberg, Germany.

出版信息

Methods Mol Biol. 2015;1340:191-200. doi: 10.1007/978-1-4939-2938-2_14.

DOI:10.1007/978-1-4939-2938-2_14

PMID:26445840

Abstract

Stratified scaffolds are promising devices finding application in the field of osteochondral tissue engineering. In this scaffold type, different biomaterials are chosen to fulfill specific features required to mimic the complex osteochondral tissue interface, including cartilage, interlayer tissue, and subchondral bone. Here, the biomaterials and fabrication methods currently used to manufacture stratified multilayered scaffolds as well as cell seeding techniques for their characterization are presented.

摘要

分层支架是一种很有前景的装置，在骨软骨组织工程领域有应用。在这种支架类型中，选择不同的生物材料来满足模拟复杂骨软骨组织界面（包括软骨、中间层组织和软骨下骨）所需的特定特性。本文介绍了目前用于制造分层多层支架的生物材料、制造方法以及用于其表征的细胞接种技术。