用于软骨组织工程的机械生物反应器。

Mechanobioreactors for Cartilage Tissue Engineering.

作者信息

Weber Joanna F, Perez Roman, Waldman Stephen D

机构信息

Department of Mechanical & Materials Engineering, Queen's University, Kingston, Canada.

Human Mobility Research Centre, Kingston General Hospital and Queen's University, Kingston, Canada.

出版信息

Methods Mol Biol. 2015;1340:203-19. doi: 10.1007/978-1-4939-2938-2_15.

DOI:10.1007/978-1-4939-2938-2_15

PMID:26445841

Abstract

Mechanical stimulation is an effective method to increase extracellular matrix synthesis and to improve the mechanical properties of tissue-engineered cartilage constructs. In this chapter, we describe valuable methods of imposing direct mechanical stimuli (compression or shear) to tissue-engineered cartilage constructs as well as some common analytical methods used to quantify the effects of mechanical stimuli after short-term or long-term loading.

摘要

机械刺激是增加细胞外基质合成以及改善组织工程软骨构建体力学性能的有效方法。在本章中，我们描述了对组织工程软骨构建体施加直接机械刺激（压缩或剪切）的重要方法，以及一些用于量化短期或长期加载后机械刺激效果的常用分析方法。