Yao Danyu, Liu Haifeng, Fan Yubo
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China.
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, People's Republic of China
Exp Biol Med (Maywood). 2016 Feb;241(3):238-45. doi: 10.1177/1535370215606994. Epub 2015 Oct 6.
The musculoskeletal system, which includes bone, cartilage, tendon/ligament, and skeletal muscle, is becoming the targets for tissue engineering because of the high need for their repair and regeneration. Numerous factors would affect the use of musculoskeletal tissue engineering for tissue regeneration ranging from cells used for scaffold seeding to the manufacture and structures of materials. The essential function of the scaffolds is to convey growth factors as well as cells to the target site to aid the regeneration of the injury. Among the variety of biomaterials used in scaffold engineering, silk fibroin is recognized as an ideal material for its impressive cytocompatibility, slow biodegradability, and excellent mechanical properties. The current review describes the advances made in the fabrication of silk fibroin scaffolds with different forms such as films, particles, electrospun fibers, hydrogels, three-dimensional porous scaffolds, and their applications in the regeneration of musculoskeletal tissues.
肌肉骨骼系统包括骨骼、软骨、肌腱/韧带和骨骼肌，由于对其修复和再生的需求很高，正成为组织工程的目标。从用于支架接种的细胞到材料的制造和结构，许多因素都会影响肌肉骨骼组织工程在组织再生中的应用。支架的基本功能是将生长因子和细胞输送到目标部位，以帮助损伤的再生。在支架工程中使用的各种生物材料中，丝素蛋白因其令人印象深刻的细胞相容性、缓慢的生物降解性和优异的机械性能而被认为是一种理想的材料。本综述描述了不同形式的丝素蛋白支架（如薄膜、颗粒、电纺纤维、水凝胶、三维多孔支架）在制造方面取得的进展及其在肌肉骨骼组织再生中的应用。
