Hedayati Mohammad T, Taghizadeh Armaki Mojtaba, Yazdani Charati Jamshid, Hedayati Newsha, Seyedmousavi Seyedmojtaba, Denning David W
Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Babol University of Medical Sciences, Babol, Iran.
J Infect Dev Ctries. 2018 Oct 31;12(10):910-918. doi: 10.3855/jidc.10476.
The number of fungal infections occurring each year in Iran is not known. As the burden of fungal disease is a measure used to assess and compare the relative impact of different type of fungal diseases on populations, we have estimated the burden of fungal diseases in Iran.
We estimated the burden of human fungal diseases based on the specific populations at risk, existing epidemiological data in both local and international databases, and modelling previously described by the LIFE program (http://www.LIFE-worldwide.org).
Among the population of Iran (79,926,270 in 2016), 6,670,813 (8.3%) individuals are estimated to suffer from a fungal infection each year. A total of 2,791,568 women aged between 15 and 50 years are estimated to suffer from recurrent vulvovaginal candidiasis, annually. In addition, considering the 13.3% prevalence rate of tinea capitis in children, a total of 2,552,624 cases per year are estimated. The estimated burden of invasive aspergillosis in the 3 groups of patients with hematologic malignancy, lung cancer and chronic pulmonary obstructive disease was 6394 (8.0 per 100,000). The estimate for the burden of allergic disease related to fungi including allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization and allergic fungal rhinosinusitis was 272,095 (340 per 100,000). Based on the 28,663 cases of HIV infection reported, an estimated 900 and 113 cases with pneumocystosis and cryptococcal meningitis are annually anticipated, respectively.
Our estimates indicate that the importance of fungal infections is high but overlooked in Iran, which warrants further actions by health care authorities.
伊朗每年发生的真菌感染病例数尚不清楚。由于真菌病负担是用于评估和比较不同类型真菌病对人群相对影响的一项指标，我们对伊朗的真菌病负担进行了估算。
我们基于特定的高危人群、本地和国际数据库中的现有流行病学数据以及LIFE项目（http://www.LIFE-worldwide.org）先前描述的模型，估算了人类真菌病的负担。
在伊朗人口（2016年为79,926,270人）中，估计每年有6,670,813人（8.3%）患有真菌感染。估计每年共有2,791,568名年龄在15至50岁之间的女性患有复发性外阴阴道念珠菌病。此外，考虑到儿童头癣患病率为13.3%，估计每年共有2,552,624例病例。血液系统恶性肿瘤、肺癌和慢性阻塞性肺疾病这三组患者中侵袭性曲霉病的估计负担为6394例（每10万人中有8.0例）。与真菌相关的过敏性疾病负担估计值，包括过敏性支气管肺曲霉病、真菌致敏性重度哮喘和变应性真菌性鼻-鼻窦炎，为272,095例（每10万人中有340例）。根据报告的28,663例艾滋病毒感染病例，预计每年分别有900例和113例患有肺孢子菌病和隐球菌性脑膜炎。
我们的估计表明，真菌感染在伊朗的重要性很高，但却被忽视了，这需要卫生保健当局采取进一步行动。
