Department of Microbiology, Faculty of Medicine, University of Ege, Izmir, Turkey.
Molecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology (LCIM), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States of America.
Mycoses. 2019 Jan;62(1):22-31. doi: 10.1111/myc.12842. Epub 2018 Sep 21.
The current number of fungal infections occurring each year in Turkey is unknown. We estimated the burden of serious human fungal diseases based on the population at risk, existing epidemiological data from 1920 to 2017 and modelling previously described by the LIFE program (http://www.LIFE-worldwide.org). Among the population of Turkey (80.8 million in 2017), approximately 1 785 811 (2.21%) people are estimated to suffer from a serious fungal infection each year. The model used predicts high prevalences of allergic fungal rhinosinusitis episodes (312 994 cases) (392/100 000), of severe asthma with fungal sensitisation (42 989 cases) (53.20 cases/100 000 adults per year), of allergic bronchopulmonary aspergillosis (32 594 cases) (40.33/100 000), of fungal keratitis (26 671 cases) (33/100 000) and of chronic pulmonary aspergillosis (5890 cases) (7.29/100 000). The estimated annual incidence for invasive aspergillosis is lower (3911 cases) (4.84/100 000 annually). Among about 22.5 million women aged 15-50 years, recurrent vulvovaginal candidiasis is estimated to occur in 1 350 371 (3342/100 000) females. The burden of three superficial fungal infections was also estimated: tinea pedis (1.79 million), tinea capitis (43 900) and onychomycosis (1.73 million). Given that the modelling estimates reported in the current study might be substantially under- or overestimated, formal epidemiological and comprehensive surveillance studies are required to validate or modify these estimates.
目前土耳其每年发生的真菌感染数量尚不清楚。我们根据风险人群、1920 年至 2017 年的现有流行病学数据以及 LIFE 项目（http://www.LIFE-worldwide.org）之前描述的模型，估算了严重人类真菌感染的负担。在土耳其人口（2017 年为 8080 万人）中，每年估计有大约 1785811 人（2.21%）患有严重真菌感染。所使用的模型预测了变应性真菌性鼻鼻窦炎发作（312994 例）（392/100000）、真菌致敏性严重哮喘（42989 例）（53.20 例/100000 名成年人/年）、变应性支气管肺曲霉病（32594 例）（40.33/100000）、真菌性角膜炎（26671 例）（33/100000）和慢性肺曲霉病（5890 例）（7.29/100000）的高患病率。侵袭性曲霉病的估计年发病率较低（3911 例）（4.84/100000 年）。在大约 2250 万 15-50 岁的妇女中，估计有 1350371 名（3342/100000）妇女会反复发作外阴阴道念珠菌病。还估计了三种浅部真菌感染的负担：足癣（179 万）、头癣（43900）和甲真菌病（173 万）。鉴于当前研究中报告的建模估计可能被大大低估或高估，因此需要进行正式的流行病学和全面的监测研究，以验证或修改这些估计。
