顶端连接复合体和肌动蛋白细胞骨架的改变及其在结直肠癌进展中的作用。
Alterations of the apical junctional complex and actin cytoskeleton and their role in colorectal cancer progression.
作者信息
Gehren Adriana Sartorio, Rocha Murilo Ramos, de Souza Waldemir Fernandes, Morgado-Díaz José Andrés
机构信息
Program of Cellular Biology; Brazilian National Cancer Institute (INCA) ; Rio de Janeiro, Brazil.
出版信息
Tissue Barriers. 2015 Feb 23;3(3):e1017688. doi: 10.1080/21688370.2015.1017688. eCollection 2015 Jul-Sep.
Colorectal cancer represents the fourth highest mortality rate among cancer types worldwide. An understanding of the molecular mechanisms that regulate their progression can prevents or reduces mortality due to this disease. Epithelial cells present an apical junctional complex connected to the actin cytoskeleton, which maintains the dynamic properties of this complex, tissue architecture and cell homeostasis. Several studies have indicated that apical junctional complex alterations and actin cytoskeleton disorganization play a critical role in epithelial cancer progression. However, few studies have examined the existence of an interrelation between these 2 components, particularly in colorectal cancer. This review discusses the recent progress toward elucidating the role of alterations of apical junctional complex constituents and of modifications of actin cytoskeleton organization and discusses how these events are interlinked to modulate cellular responses related to colorectal cancer progression toward successful metastasis.
结直肠癌是全球癌症类型中死亡率第四高的癌症。了解调节其进展的分子机制可以预防或降低因这种疾病导致的死亡率。上皮细胞存在与肌动蛋白细胞骨架相连的顶端连接复合体，该复合体维持了这种复合体的动态特性、组织结构和细胞内稳态。多项研究表明，顶端连接复合体改变和肌动蛋白细胞骨架紊乱在上皮癌进展中起关键作用。然而，很少有研究探讨这两个成分之间的相互关系，特别是在结直肠癌中。这篇综述讨论了在阐明顶端连接复合体成分改变和肌动蛋白细胞骨架组织修饰的作用方面的最新进展，并讨论了这些事件如何相互关联以调节与结直肠癌进展至成功转移相关的细胞反应。
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