镍催化吡啶的对位碳氢键活化及烯丙基芳烃的区域选择性氢杂芳基化反应的调控
Nickel-catalysed para-CH activation of pyridine with switchable regioselective hydroheteroarylation of allylarenes.
作者信息
Lee Wei-Chih, Chen Chien-Hung, Liu Cheng-Yuan, Yu Ming-Shiuan, Lin Yung-Huei, Ong Tiow-Gan
机构信息
Institute of Chemistry, Academia Sinica, Taipei, Taiwan, Republic of China.
出版信息
Chem Commun (Camb). 2015 Dec 14;51(96):17104-7. doi: 10.1039/c5cc07455j.
para-CH activation of pyridine with allylbenzene is described by Ni/Al cooperative catalysis in combination with a bulkier NHC ligand and a Lewis acid, leading to linear hydroheteroarylation products. Interestingly, the branch selectivity can be achieved by using the combination of a less sterically hindered amino-NHC ligand and AlMe3 through tandem reaction of facile alkene isomerization followed by a slow CH bond activation process.
通过镍/铝协同催化，结合体积更大的氮杂环卡宾配体和路易斯酸，实现了吡啶与烯丙基苯的对位碳氢键活化，得到线性氢杂芳基化产物。有趣的是，通过使用空间位阻较小的氨基氮杂环卡宾配体和三甲基铝的组合，通过烯烃异构化的串联反应，随后是缓慢的碳氢键活化过程，可以实现支链选择性。
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