Nichols C J, Mieler W F
Eye Institute, Medical College of Wisconsin, Milwaukee 53226.
Ophthalmology. 1989 Oct;96(10):1535-40. doi: 10.1016/s0161-6420(89)32695-9.
Systemic lupus erythematosus (SLE) is known to cause various forms of ocular problems, including severe retinal vaso-occlusive disease. Procainamide is one of many drugs that may cause a lupus-like syndrome which resembles SLE but can be distinguished through clinical features and laboratory studies. Presented is a patient with severe vaso-occlusive retinopathy on high-dose procainamide therapy. Associated clinical, laboratory, and pathologic findings suggest the diagnosis of drug-induced lupus and exclude other vasculitic or inflammatory etiologies. This represents the first documented case of retinal disease attributed to procainamide-induced lupus.
系统性红斑狼疮（SLE）已知会引发多种眼部问题，包括严重的视网膜血管闭塞性疾病。普鲁卡因酰胺是众多可能导致类狼疮综合征的药物之一，该综合征与SLE相似，但可通过临床特征和实验室检查加以区分。本文介绍了一名在接受高剂量普鲁卡因酰胺治疗时出现严重血管闭塞性视网膜病变的患者。相关的临床、实验室和病理检查结果提示为药物性狼疮的诊断，并排除了其他血管炎或炎症性病因。这是首例有文献记载的由普鲁卡因酰胺诱发的狼疮所致视网膜疾病病例。
