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创造具有人类配子生成能力和人类妊娠能力的人-非人嵌合体的伦理问题。

Ethical aspects of creating human-nonhuman chimeras capable of human gamete production and human pregnancy.

作者信息

Palacios-González César

机构信息

Institute for Science Ethics and Innovation, The University of Manchester, Room 3.383, Stopford Building, Oxford Road, Manchester, M13 9PL, UK.

出版信息

Monash Bioeth Rev. 2015 Jun-Sep;33(2-3):181-202. doi: 10.1007/s40592-015-0031-1.

DOI:10.1007/s40592-015-0031-1
PMID:26458367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4631712/
Abstract

In this paper I explore some of the moral issues that could emerge from the creation of human-nonhuman chimeras (HNH-chimeras) capable of human gamete production and human pregnancy. First I explore whether there is a cogent argument against the creation of HNH-chimeras that could produce human gametes. I conclude that so far there is none, and that in fact there is at least one good moral reason for producing such types of creatures. Afterwards I explore some of the moral problems that could emerge from the fact that a HNH-chimera could become pregnant with a human conceptus. I focus on two sets of problems: problems that would arise by virtue of the fact that a human is gestated by a nonhuman creature, and problems that would emerge from the fact that such pregnancies could affect the health of the HNH-chimera.

摘要

在本文中,我探讨了一些可能因创造出能够产生人类配子并实现人类怀孕的人类-非人类嵌合体(HNH-嵌合体)而出现的道德问题。首先,我探讨是否存在一个有说服力的论点来反对创造能够产生人类配子的HNH-嵌合体。我得出的结论是,到目前为止还没有,事实上,创造这类生物至少有一个很好的道德理由。之后,我探讨了HNH-嵌合体可能怀有人类胚胎这一事实可能引发的一些道德问题。我关注两组问题:一组是由于人类由非人类生物孕育而产生的问题,另一组是这类怀孕可能影响HNH-嵌合体健康而出现的问题。

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本文引用的文献

1
Human dignity and the creation of human-nonhuman chimeras.人类尊严与人类-非人类嵌合体的创造。
Med Health Care Philos. 2015 Nov;18(4):487-99. doi: 10.1007/s11019-015-9644-7.
2
Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras.重温伊卡洛斯的飞行:用大型动物嵌合体制造源自 PSC 的人类器官。
Cell Stem Cell. 2014 Oct 2;15(4):406-409. doi: 10.1016/j.stem.2014.09.013.
3
What is the harm in harmful conception? On threshold harms in non-identity cases.有害受孕有何危害?论非同一性情形中的临界危害。
Theor Med Bioeth. 2014 Oct;35(5):337-51. doi: 10.1007/s11017-014-9303-7.
4
Xenografting of testicular tissue pieces: 12 years of an in vivo spermatogenesis system.睾丸组织块的异种移植:12年的体内精子发生系统。
Reproduction. 2014 Nov;148(5):R71-84. doi: 10.1530/REP-14-0249. Epub 2014 Aug 22.
5
How useful is the concept of the 'harm threshold' in reproductive ethics and law?“伤害阈值”概念在生殖伦理与法律中具有多大的实用性?
Theor Med Bioeth. 2014 Oct;35(5):321-36. doi: 10.1007/s11017-014-9302-8.
6
Multiplex parenting: IVG and the generations to come.多元养育:体外配子生成与未来几代人。
J Med Ethics. 2014 Nov;40(11):752-8. doi: 10.1136/medethics-2013-101810. Epub 2014 Mar 7.
7
Reframing the ethical issues in part-human animal research: the unbearable ontology of inexorable moral confusion.重新构建部分人类-动物研究中的伦理问题:无法回避的道德困惑的难以承受的本体论。
Am J Bioeth. 2012;12(9):17-25. doi: 10.1080/15265161.2012.699139.
8
Chimeras, moral status, and public policy: implications of the abortion debate for public policy on human/nonhuman chimera research.嵌合体、道德地位与公共政策:堕胎辩论对人类/非人类嵌合体研究公共政策的影响。
J Law Med Ethics. 2010 Summer;38(2):238-50. doi: 10.1111/j.1748-720X.2010.00484.x.
9
Human-animal chimeras for vaccine development: an endangered species or opportunity for the developing world?人类-动物嵌合体用于疫苗开发:濒危物种还是发展中国家的机会?
BMC Int Health Hum Rights. 2010 May 19;10:8. doi: 10.1186/1472-698X-10-8.
10
Animal eggs for stem cell research: a path not worth taking.用于干细胞研究的动物卵子:一条不值得走的路。
Am J Bioeth. 2008 Dec;8(12):18-32. doi: 10.1080/15265160802559161.