Brun Alejandro
Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Almentaria (INIA), Ctra de Valdeolmos-El Casar s/n, Valdeolmos, 28130, Madrid, Spain.
Methods Mol Biol. 2016;1349:1-24. doi: 10.1007/978-1-4939-3008-1_1.
A high number of infectious diseases affecting livestock and companion animals are caused by pathogens of viral etiology. Ensuring the maximum standards of quality and welfare in animal production requires developing effective tools to halt and prevent the spread of those infectious diseases affecting animal husbandry. To date, one of the best strategies is to implement vaccination policies whenever possible. However many of the currently manufactured vaccines relies in classical vaccine technologies (killed or attenuated vaccines) which, under some circumstances, may not be optimal in terms of safety or adequate for widespread application in disease-free countries at risk of disease introduction. One step ahead is needed to improve and adapt vaccine manufacturing to the use of new generation vaccine technologies already tested in experimental settings. Here we present in the context of animal viral diseases of veterinary interest, an overview of some current vaccine technologies that can be approached for virus pathogens with a brief insight in the type of immunity elicited.
大量影响家畜和伴侣动物的传染病是由病毒病原体引起的。要确保动物生产达到最高质量和福利标准,就需要开发有效的工具来阻止和预防那些影响畜牧业的传染病的传播。迄今为止,最佳策略之一是尽可能实施疫苗接种政策。然而,目前生产的许多疫苗依赖于传统疫苗技术(灭活或减毒疫苗),在某些情况下,这些技术在安全性方面可能并非最佳选择,或者不足以在有疾病传入风险的无病国家广泛应用。需要向前迈进一步,改进疫苗生产并使其适应已在实验环境中测试过的新一代疫苗技术的应用。在此,我们结合具有兽医意义的动物病毒性疾病,概述一些当前可用于病毒病原体的疫苗技术,并简要介绍所引发的免疫类型。