Pals S T, Horst E, Ossekoppele G J, Figdor C G, Scheper R J, Meijer C J
Department of Pathology, Free University, Amsterdam, The Netherlands.
Blood. 1989 Mar;73(4):885-8.
To investigate whether the lymphocyte homing receptor (LHR), an adhesion molecule believed to play an important role in the control of normal lymphocyte circulation, influences the spread of non-Hodgkin's lymphoma (NHL), expression of LHR was examined in 107 NHL of various histologic and immunophenotypic subclasses. This analysis revealed that whereas NHL with a putative derivation from recirculating mature T and B lymphocytes almost invariably express high levels of LHR, those akin to sessile mature or immature lymphocytes tend to express lower levels of LHR. Furthermore, in a survey among diffuse large-cell lymphomas of the B-lineage, the tumors of 11 of 13 patients with stage III/IV disease expressed moderate to high levels of LHR, whereas only two of 17 patients with stage I/II disease had tumors that did so. These findings suggest that LHR is involved in the dissemination of NHL.
为了研究淋巴细胞归巢受体（LHR），一种被认为在正常淋巴细胞循环控制中起重要作用的黏附分子，是否影响非霍奇金淋巴瘤（NHL）的扩散，我们检测了107例不同组织学和免疫表型亚类的NHL中LHR的表达。该分析显示，推测源自再循环成熟T和B淋巴细胞的NHL几乎总是表达高水平的LHR，而那些类似于固定成熟或未成熟淋巴细胞的NHL倾向于表达较低水平的LHR。此外，在一项对B细胞系弥漫性大细胞淋巴瘤的调查中，13例III/IV期疾病患者中有11例的肿瘤表达中度至高水平的LHR，而17例I/II期疾病患者中只有2例的肿瘤是如此。这些发现表明LHR参与了NHL的扩散。
