Eldridge R, Sweet R, Lake R, Ziegler M, Shapiro A K
Neurology. 1977 Feb;27(2):115-24. doi: 10.1212/wnl.27.2.115.
Eighty-one patients and relatives with Tourette's syndrome, members of 21 selected families, participated in a 1-day clinic. In 12 of the 13 Jewish families and six of the eight non-Jewish families, there were multiple members with motor and vocal tics by observation or history. Males predominated among those with persistent symptoms, but among those with spontaneous clearing, females predominated. Twelve propositi had troublesome sexual and aggressive impulses, differing only quantitatively from normal. No evidence of abnormality was found in plasma dopamine beta hydroxylase, or norepinephrine levels.
81名患有妥瑞氏综合征的患者及亲属（来自21个选定家庭）参加了为期1天的门诊。在13个犹太家庭中的12个以及8个非犹太家庭中的6个，通过观察或病史发现有多名成员存在运动性和发声性抽动。在有持续性症状的患者中男性占主导，但在症状自发缓解的患者中女性占主导。12名先证者有令人烦恼的性冲动和攻击冲动，与正常人的差异仅在数量上。未发现血浆多巴胺β羟化酶或去甲肾上腺素水平有异常证据。
