Murdoch Childrens Research Institute, Royal Children's Hospital and Department of Pediatrics, University of Melbourne, Melbourne VIC, Australia.
Dev Cell. 2015 Oct 12;35(1):5-6. doi: 10.1016/j.devcel.2015.09.023.
Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by a young crowd.
尽管我们知道间充质祖细胞会在肾脏中产生肾单位，但是它们如何平衡自我更新与分化仍然不清楚。在本期《发育细胞》中，Chen 等人（2015）表明，肾单位祖细胞会衰老，但并非不可逆转：年轻的祖细胞群体可以“使老的祖细胞年轻化”。
