肾单位祖细胞的生命周期。
The Life Cycle of the Nephron Progenitor.
机构信息
Murdoch Childrens Research Institute, Royal Children's Hospital and Department of Pediatrics, University of Melbourne, Melbourne VIC, Australia.
出版信息
Dev Cell. 2015 Oct 12;35(1):5-6. doi: 10.1016/j.devcel.2015.09.023.
PMID:26460940
Abstract
Although we know that mesenchymal progenitors give rise to nephrons in the kidney, how they balance self-renewal versus differentiation is still unclear. In this issue of Developmental Cell, Chen et al. (2015) show that nephron progenitors age, but not necessarily irreversibly: old progenitors can be "rejuvenated" by a young crowd.
摘要
尽管我们知道间充质祖细胞会在肾脏中产生肾单位，但是它们如何平衡自我更新与分化仍然不清楚。在本期《发育细胞》中，Chen 等人（2015）表明，肾单位祖细胞会衰老，但并非不可逆转：年轻的祖细胞群体可以“使老的祖细胞年轻化”。
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