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PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK.

作者信息

Harrison Ewan M, Ba Xiaoliang, Blane Beth, Ellington Matthew J, Loeffler Anette, Hill Robert L R, Holmes Mark A, Peacock Sharon J

机构信息

Department of Medicine, University of Cambridge, Cambridge, UK

Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.

出版信息

J Antimicrob Chemother. 2016 Jan;71(1):268-9. doi: 10.1093/jac/dkv317. Epub 2015 Oct 12.

DOI:10.1093/jac/dkv317
PMID:26462986
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4681373/
Abstract
摘要

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2
Missense mutations in PBP2A Affecting ceftaroline susceptibility detected in epidemic hospital-acquired methicillin-resistant Staphylococcus aureus clonotypes ST228 and ST247 in Western Switzerland archived since 1998.1998年以来存档于瑞士西部的医院流行获得性耐甲氧西林金黄色葡萄球菌克隆型ST228和ST247中检测到影响头孢洛林敏感性的PBP2A错义突变。
Antimicrob Agents Chemother. 2015 Apr;59(4):1922-30. doi: 10.1128/AAC.04068-14. Epub 2015 Jan 12.
3
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mBio. 2014 May 13;5(3):e00985-13. doi: 10.1128/mBio.00985-13.
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Analysis of Staphylococcus aureus clinical isolates with reduced susceptibility to ceftaroline: an epidemiological and structural perspective.对头孢洛林敏感性降低的金黄色葡萄球菌临床分离株的分析：流行病学和结构视角
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PLoS One. 2013 Jul 15;8(7):e68463. doi: 10.1371/journal.pone.0068463. Print 2013.
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Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline.耐甲氧西林金黄色葡萄球菌中 ceftaroline MIC 值升高的特性研究
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