新兴技术在下一代即时检测中的应用。

Emerging Technologies for Next-Generation Point-of-Care Testing.

机构信息

Institute of Clinical Chemistry and Pathobiochemistry, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, D-81675 Munich, Germany.

出版信息

Trends Biotechnol. 2015 Nov;33(11):692-705. doi: 10.1016/j.tibtech.2015.09.001. Epub 2015 Oct 17.

DOI:10.1016/j.tibtech.2015.09.001

PMID:26463722

Abstract

Considerable advances in point-of-care testing (POCT) devices stem from innovations in cellphone (CP)-based technologies, paper-based assays (PBAs), lab-on-a-chip (LOC) platforms, novel assay formats, and strategies for long-term reagent storage. Various commercial CP platforms have emerged to provide cost-effective mobile health care and personalized medicine. Such assay formats, as well as low-cost PBAs and LOC-based assays, are paving the way to robust, automated, simplified, and cost-effective POCT. Strategies have also been devised to stabilize reagent storage and usage at ambient temperature. Nevertheless, successful commercialization and widespread implementation of such clinically viable technologies remain subject to several challenges and pending issues.

摘要

得益于手机（CP）技术、基于纸的检测（PBA）、芯片实验室（LOC）平台、新型检测方法以及长期试剂储存策略方面的创新，即时检测（POCT）设备取得了显著进展。各种商用 CP 平台的出现，为提供经济实惠的移动医疗和个性化医疗服务创造了条件。这些检测方法以及低成本的 PBA 和基于 LOC 的检测方法，为开发强大、自动化、简化和经济高效的 POCT 铺平了道路。此外，还制定了稳定试剂储存和常温使用的策略。然而，这些具有临床应用价值的技术要想成功实现商业化并得到广泛应用，仍需应对诸多挑战和待解决的问题。