Mutalik Chinmaya, Sharma Shashwat, Yougbaré Sibidou, Chen Chih-Yu, Kuo Tsung-Rong
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 11031, Taiwan.
Center for Airborne Infection & Transmission Science, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
Int J Nanomedicine. 2025 May 7;20:5817-5836. doi: 10.2147/IJN.S521442. eCollection 2025.
Recent nanotechnological advancements have resulted in a paradigm shift in biosensing applications through the advent of nanoplasmonic biosensors. These devices integrate nanomaterials with phenomena like surface plasmon resonance (SPR) and localized SPR (LSPR) to address the critical diagnostic and analytical needs across medicine, food safety, and drug discovery. Leveraging metals like gold and silver, these sensors exhibit enhanced optical and electronic properties, enabling the detection of biomolecules at ultralow concentrations. However, despite their transformative potential, challenges concerning stability, reproducibility, cost-efficiency, and scalability impede widespread implementation. This review offers a rigorous analysis of nanoplasmonic biosensors, emphasizing their underlying operational mechanisms and diverse applications. It also delves into design paradigms, fabrication protocols, and optimization strategies while concurrently examining prevailing challenges and prospective advancements. Furthermore, it highlights emerging trends, such as hybrid plasmonic nanostructures, conferring advantages in miniaturization, automation, and high-throughput analysis, thereby establishing a robust foundation for future innovation in the field.
最近的纳米技术进步通过纳米等离子体生物传感器的出现，导致了生物传感应用的范式转变。这些设备将纳米材料与表面等离子体共振（SPR）和局域表面等离子体共振（LSPR）等现象相结合，以满足医学、食品安全和药物发现等领域的关键诊断和分析需求。利用金和银等金属，这些传感器具有增强的光学和电子特性，能够检测超低浓度的生物分子。然而，尽管它们具有变革潜力，但稳定性、可重复性、成本效益和可扩展性等挑战阻碍了其广泛应用。本综述对纳米等离子体生物传感器进行了严格分析，强调了其潜在的运行机制和多样的应用。它还深入探讨了设计范式、制造协议和优化策略，同时审视了当前面临的挑战和未来的进展。此外，它突出了新兴趋势，如混合等离子体纳米结构，在小型化、自动化和高通量分析方面具有优势，从而为该领域未来的创新奠定了坚实基础。
