Wang Lei, Ma Ling, Wang Xinli, Li Bing, Guo Shan, Qiao Qingdong
Department of Urology I, Xinxiang Central Hospital Xinxiang, Henan, China ; Department of Urology, Chinese PLA General Hospital, Medical School of Chinese PLA Beijing, China.
Department of Urology II, Xinxiang Central Hospital Xinxiang, Henan, China.
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9397-403. eCollection 2015.
Early prostate cancer antigen 2 (EPCA-2), a kind of nuclear matrix protein, may relate to prostate cancer. However, the association of EPCA-2 level in serum with prostate diseases has not been clarified in Chinese Han population.
EPCA-2 and prostate-specific antigen (PSA) levels in serum were detected by enzyme linked immunosorbent assay in 116 patients with prostate cancer (PCa), 342 patients with benign prostatic hyperplasia (BPH), and 174 healthy controls (Control) in Chinese population. Associations of serum EPCA-2 and PSA level with prostate diseases were analyzed by ANOVA. Comparison of diagnostic effect for prostate cancer between EPCA-2 and PSA was evaluated by Receiver Operator Curve, Chi-square test, and others.
Serum EPCA-2 and PSA levels in PCa group were significantly higher than BPH and Control group (EPCA-2: F=200.05, P<0.01; PSA: F=210.65, P<0.01). However, EPCA-2 levels in the prostate cancers with different pathological grade were no significant difference. Furthermore, for detection of prostate cancer, EPCA-2 had a sensitivity of 81.9% and a specificity of 87.6%.
Serum EPCA-2 could be used as a potential serological marker to diagnose prostate cancer in Chinese Han population, which was more specific than PSA and did not associate with pathological grades of prostate cancer.
早期前列腺癌抗原2（EPCA - 2）是一种核基质蛋白，可能与前列腺癌有关。然而，在中国汉族人群中，血清EPCA - 2水平与前列腺疾病的关系尚未明确。
采用酶联免疫吸附测定法检测了116例前列腺癌（PCa）患者、342例良性前列腺增生（BPH）患者和174例健康对照者（对照组）血清中的EPCA - 2和前列腺特异性抗原（PSA）水平。采用方差分析血清EPCA - 2和PSA水平与前列腺疾病的关系。通过受试者工作特征曲线、卡方检验等评估EPCA - 2和PSA对前列腺癌的诊断效果。
PCa组血清EPCA - 2和PSA水平显著高于BPH组和对照组（EPCA - 2：F = 200.05，P < 0.01；PSA：F = 210.65，P < 0.01）。然而，不同病理分级的前列腺癌中EPCA - 2水平无显著差异。此外，对于前列腺癌的检测，EPCA - 2的敏感性为81.9%，特异性为87.6%。
血清EPCA - 2可作为中国汉族人群诊断前列腺癌的潜在血清学标志物，其比PSA更具特异性，且与前列腺癌的病理分级无关。
