Jain Sharad R, Shah Komal H, Acharya Himanshu N, Barot Kaushik, Sharma Kamal H
Department of Cardiology, U. N. Mehta Institute of Cardiology and Research Center, BJ Medical College and Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat 380 016, India.
Department of Research, U. N. Mehta Institute of Cardiology and Research Center, BJ Medical College and Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat 380 016, India.
Int J Chronic Dis. 2015;2015:365217. doi: 10.1155/2015/365217. Epub 2015 Jul 30.
Background. Metabolic syndrome is a cluster of risk factors leading to the development of atherosclerotic cardiovascular diseases. We aimed to evaluate the prevalence of metabolic syndrome (MS) and its predictors in young and apparently healthy Gujarati individuals. Methods. This population based cross-sectional study involved a total of 1500 healthy adults of 20-40 years of age. Demographic details and clinical data such as body mass index (BMI), waist circumference (WC), and blood pressure were measured along with the estimations of lipoprotein (a), total cholesterol (TC), triglyceride (TG), total lipid, LDL/HDL ratio, TC/HDL ratio, and fasting blood glucose (FBS). Results. Overall in young Gujarati population (20-40 years) prevalence rates of MS were 16.0% (male: 21.5%; female: 10.8%) where the metabolic abnormalities increased with advanced age as 9.56% of the young population (20-30 years) had MS, in contrast to the 24.57% in the old (31-40 years). Odds ratio analysis had indicated BMI (1.120; 95% CI: 1.077-1.163; P < 0.0001) as the strongest risk factor for MS closely followed by advancing age (1.100; 95% CI: 1.061-1.139; P < 0.0001) levels. Conclusion. Prevalence of metabolic syndrome in young Gujarati population reinforces the need for early life style intervention and awareness programs in this ethnic group.
背景。代谢综合征是一组导致动脉粥样硬化性心血管疾病发生的危险因素。我们旨在评估年轻且看似健康的古吉拉特人群中代谢综合征(MS)的患病率及其预测因素。方法。这项基于人群的横断面研究共纳入了1500名年龄在20 - 40岁的健康成年人。测量了人口统计学细节和临床数据,如体重指数(BMI)、腰围(WC)和血压,同时还对脂蛋白(a)、总胆固醇(TC)、甘油三酯(TG)、总脂质、低密度脂蛋白/高密度脂蛋白比值、总胆固醇/高密度脂蛋白比值以及空腹血糖(FBS)进行了测定。结果。总体而言,在年轻的古吉拉特人群(20 - 40岁)中,MS的患病率为16.0%(男性:21.5%;女性:10.8%),其中代谢异常随着年龄增长而增加,9.56%的年轻人群(20 - 30岁)患有MS,相比之下,老年人群(31 - 40岁)的患病率为24.57%。比值比分析表明BMI(1.120;95%置信区间:1.077 - 1.163;P < 0.0001)是MS最强的危险因素,紧随其后的是年龄增长(1.100;95%置信区间:1.061 - 1.139;P < 0.0001)。结论。年轻古吉拉特人群中代谢综合征的患病率强化了在该族群中开展早期生活方式干预和提高认识项目的必要性。