Zaleski Amanda, Capizzi Jeffrey, Ballard Kevin D, Troyanos Christopher, Baggish Aaron, D'Hemecourt Pierre, Thompson Paul D, Parker Beth
Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA ; Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA.
J Sports Med (Hindawi Publ Corp). 2013;2013:487567. doi: 10.1155/2013/487567. Epub 2013 May 7.
Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL; P < 0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL; P < 0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P < 0.01 and P < 0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.
剧烈的耐力运动可增加炎症标志物并急性增加心血管风险；然而，他汀类药物可能会减轻这种反应。我们测量了37名接受他汀类药物治疗的跑步者和43名未接受他汀类药物治疗的对照组在参加2011年波士顿马拉松比赛时的血清p-选择素水平。在比赛前一天（PRE）、比赛结束后1小时内（FINISH）以及比赛结束后24小时（POST）采集静脉血样。运动后立即出现的p-选择素升高在服用他汀类药物的使用者中（PRE至FINISH：20.5±19.4 ng/mL）低于对照组（PRE至FINISH：30.9±27.1 ng/mL；P<0.001）。运动后24小时p-选择素的升高在服用他汀类药物的使用者中（PRE至POST：21.5±26.6 ng/mL）也低于对照组（PRE至POST：29.3±31.9 ng/mL；P<0.001）。此外，无论药物治疗情况如何，LDL-C在FINISH和POST时均与p-选择素呈正相关（分别为P<0.01和P<0.05），这表明较低水平的LDL-C与运动引起的炎症反应减轻有关。我们得出结论，他汀类药物可抑制马拉松赛后运动诱导的p-选择素升高，并且对马拉松的炎症反应与LDL-C水平直接相关。
