Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT 06102, USA.
Clin J Sport Med. 2011 Mar;21(2):126-30. doi: 10.1097/JSM.0b013e31820edfa6.
Air travel and exercise change hemostatic parameters. This study investigated the effect of air travel on exercise-induced coagulation and fibrinolysis in endurance athletes.
A prospective longitudinal study.
The 114th Boston Marathon (April 19, 2010).
Forty-one adults were divided into travel (T: 23 participants, living >4-hour plane flight from Boston) and nontravel (C: 18 participants, living <2-hour car trip from Boston) groups.
Age, anthropometrics, vital signs, training mileage, and finishing time were collected.
Subjects provided venous blood samples the day before (PRE), immediately after (FINISH), and the day following the marathon after returning home (POST). Blood was analyzed for thrombin-antithrombin complex (TAT), tissue plasminogen activator (t-PA), hematocrit (Hct), and the presence of Factor V Leiden R506Q mutation.
Thrombin-antithrombin complex increased more in T subjects in PRE to FINISH samples (5.0 ± 4.0 to 12.9 ± 15.6 μg/L) than in C subjects (4.0 ± 1.2 to 6.1 ± 1.2 μg/L; P = 0.02 for comparison). The t-PA increased in both the T (5.4 ± 2.3 to 25.1 ± 12.2 ng/mL) and C (5.6 ± 2.0 to 27.7 ± 11.3 ng/mL) groups in PRE to FINISH samples, and this response did not differ between groups (P = 0.23 for comparison). Both groups exhibited similar t-PA and TAT values at POST that were not different than PRE (all P > 0.35). Age was related to the FINISH TAT values in T (r = 0.19; P = 0.04) but not in C (r = 0.03; P = 0.53) subjects.
Results suggest that the combination of air travel and marathon running induces an acute hypercoaguable state; this hemostatic imbalance is exaggerated with increasing age.
航空旅行和运动改变止血参数。本研究调查了航空旅行对耐力运动员运动诱导的凝血和纤溶的影响。
前瞻性纵向研究。
第 114 届波士顿马拉松（2010 年 4 月 19 日）。
41 名成年人分为旅行组（T：23 名参与者，居住在距离波士顿 4 小时以上飞机航程的地方）和非旅行组（C：18 名参与者，居住在距离波士顿 2 小时车程以内的地方）。
年龄、人体测量学、生命体征、训练里程和完赛时间。
受试者在马拉松比赛前一天（PRE）、完赛后即刻（FINISH）和返回后第二天（POST）提供静脉血样。分析血液中的凝血酶-抗凝血酶复合物（TAT）、组织型纤溶酶原激活物（t-PA）、红细胞压积（Hct）和因子 V Leiden R506Q 突变的存在情况。
与 C 组相比（4.0 ± 1.2 至 6.1 ± 1.2 μg/L；比较时 P = 0.02），T 组的 TAT 在 PRE 到 FINISH 样本中增加更多（5.0 ± 4.0 至 12.9 ± 15.6 μg/L）。T（5.4 ± 2.3 至 25.1 ± 12.2 ng/mL）和 C（5.6 ± 2.0 至 27.7 ± 11.3 ng/mL）两组在 PRE 到 FINISH 样本中均出现 t-PA 增加，且两组间无差异（比较时 P = 0.23）。两组在 POST 时的 t-PA 和 TAT 值均与 PRE 时相似（均 P > 0.35）。T 组的 FINISH TAT 值与年龄相关（r = 0.19；P = 0.04），而 C 组无相关性（r = 0.03；P = 0.53）。
结果表明，航空旅行和马拉松跑步的结合会引起急性高凝状态；这种止血失衡随着年龄的增长而加剧。
