Sechi Sara, Chiavolelli Francesca, Spissu Nicoletta, Di Cerbo Alessandro, Canello Sergio, Guidetti Gianandrea, Fiore Filippo, Cocco Raffaella
Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via Vienna 2, 07100 Sassari, Italy.
SANYpet S.p.a., Research and Development Department, Via Austria 3, Bagnoli di Sopra, 35023 Padua, Italy.
J Vet Med. 2015;2015:412501. doi: 10.1155/2015/412501. Epub 2015 Jun 23.
Biological aging is characterized by a progressive accumulation of oxidative damage and decreased endogenous antioxidant defense mechanisms. The production of oxidants by normal metabolism damages proteins, lipids, and nucleotides, which may contribute to cognitive impairment. In this study 36 dogs were randomly divided into four groups and fed croquettes of different compositions for 6 months. We monitored derivatives of reactive oxygen metabolites (dROMs) and biological antioxidant potential (BAP) levels in dogs' plasma samples as well as brain-derived neurotrophic factor (BDNF) serum levels at the beginning and at the end of the dietary regime. Our results showed that a dietary regime, enriched with antioxidants, induced a significant decrease of plasma levels of dROMs (p < 0.005) and a significant increase in BDNF serum levels (p < 0.005) after six months. Thus, we hypothesized a possible role of the diet in modulating pro- and antioxidant species as well as BDNF levels in plasma and serum, respectively. In conclusion the proposed diet enriched with antioxidants might be considered a valid alternative and a valuable strategy to counteract aging-related cognitive decline in elderly dogs.
生物衰老的特征是氧化损伤的逐渐积累和内源性抗氧化防御机制的下降。正常代谢产生的氧化剂会损害蛋白质、脂质和核苷酸，这可能导致认知障碍。在本研究中，36只狗被随机分为四组，并喂食不同成分的肉饼6个月。我们在饮食方案开始和结束时监测了狗血浆样本中的活性氧代谢产物衍生物（dROMs）和生物抗氧化潜力（BAP）水平，以及脑源性神经营养因子（BDNF）血清水平。我们的结果表明，富含抗氧化剂的饮食方案在6个月后导致血浆dROMs水平显著降低（p < 0.005），BDNF血清水平显著升高（p < 0.005）。因此，我们推测饮食可能分别在调节血浆和血清中的促氧化剂和抗氧化剂种类以及BDNF水平方面发挥作用。总之，所提出的富含抗氧化剂的饮食可能被认为是一种有效的替代方法和有价值的策略，以对抗老年犬与衰老相关的认知衰退。
